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Table 2 Comparison of respiratory parameters between the applied ventilation modes

From: Effects of three spontaneous ventilation modes on respiratory drive and muscle effort in COVID-19 pneumonia patients

 

ACV

PSV 10 (5–15 cmH2O)

APRV

BIPAP (20/10 cmH2O)

P

Respiratory frequency (breaths/min)

24.12 (23.31–26.42)

19.26 (16.74–21.61)

19.59 (12.14–29.35)

20.11 (13.53–24.94)

0.998

Tidal volume (ml/Kg)

4.37 (4.02–5.95)

7.65 (4.49–9.28)

5.86 (3.78–6.03)

4.58 (3.77–7.08)

0.131

pH (units)

7.33 (7.25–7.43)

7.35 (7.31–7.44)

7.33 (7.26–7.41)

7.32 (7.26–7.38)

0.965

PCO2 (mmHg)

54 (44–62)

43 (24–55)

57 (42–65)

53 (43–67)

0.721

PO2 (mmHg)

81 (77–95)

80 (63–112)

74 (64–103)

79 (68–105)

0.651

FiO2 (%)

40 (40–50)

40 (40–50)

40 (40–50)

40(40–50)

N/A

Total PEEP (cmH2O)

11.05 (10.31–11.55)

10.05 (8.42–10.50)

10.00 (4.45–10.81)

10.04 (9.51–10.67)

N/A

Ers (cmH2O/L)

25.98 (20.17–37.78)

22.24 (20.09–29.19)

25.69 (18.96–29.50)

24.75 (14.75–29.68)

0.688

Rrs (cmH2O/L/s)

12.15 (10.05–14.61)

15.10 (11.50–18.58)

14.76 (11.99–20.85)

11.84 (10.06–12.67)

0,117

P0.1 (cmH2O)

N/A

6.12 (3.69–8.26)

5.82 (4.13–10.89)

5.80 (4.22–8.85)

0.907

Delta Muscle Pressure (cmH2O)

N/A

13.04 (10.06–17.35)

15.77 (10.85–23.38)

16.16 (6.92–17.76)

0.556

PTPpmus (cmH2O.s/min)

N/A

135.17 (96.55–175.27)

148.74 (112.38–259.94)

156.95 (84.18–335.11)

0.716

WOB (Joule/min)

N/A

13.52 (5.34–18.97)

10.54 (4.87–24.75)

14.39 (4.10–23.78)

0.973

PDist_EM (cmH2O)

N/A

14.81 (13.97–16.03)*

20.74 (19.75–22.39)

18.91 (17.72–23.65)

< 0.001

  1. ACV Assist-control volume ventilation, PSV Pressure support ventilation (Inspiratory pressure), APRV Airway pressure release ventilation (High pressure 20 cmH2O, expiration limited to 75% expiratory flow), BIPAP biLevel mode, PEEP Positive end-expiratory pressure, Ers Elastance respiratory system, Rrs Resistance respiratory system, P0.1 Airway occlusion pressure generated at the airways during the first 100 ms of an inspiratory effort, PTPpmus Muscle pressure time product during the inspiratory period, WOB Patient work of breathing, PDist_EM Total distending pressure by equation motion, N/A Not applicable
  2. *p < 0.05 between PSV versus APRV or BIPAP