Skip to main content

Table 3 Baseline characteristics and adverse events of tuberculosis patients according to NAT2 phenotype

From: Risk adjustment model for tuberculosis compared to non-tuberculosis mycobacterium or latent tuberculosis infection: Center for Personalized Precision Medicine of Tuberculosis (cPMTb) cohort database

 

NAT2 phenotype

P-values

 

Rapid acetylator (N = 361)

Intermediate (N = 443)

Slow/ultraslow (N = 117)

Rapid vs. intermediate

Rapid vs. slow

Intermediate vs. slow

Demographics

 Age

59 [47,69]

60 [47,72]

60 [46,68]

0.664

0.989

0.824

 Male sex

247 (68.4%)

293 (66.1%)

79 (67.5%)

0.527

0.946

0.852

 Body mass index (kg/m2)

21.3 [19.2, 23.5]

21.8 [19.4, 23.8]

21.8 [19.6, 23.7]

0.090

0.286

0.987

 Previous TB history

63 (17.5%)

62 (14.2%)

19 (16.2%)

0.232

0.863

0.675

Comorbidity

 Diabetes

52 (24.5%)

70 (27.9%)

16 (21.9%)

0.477

0.770

0.386

 COPD

2 (0.9%)

9 (3.6%)

1 (1.4%)

0.120

 > 0.999

0.563

 HTN

50 (23.6%)

36 (14.3%)

15 (20.5%)

0.015

0.710

0.272

Laboratory findings

 WBC, /μL*1000

6.2 [5.0, 7.8]

6.5 [5.17, 8.16]

6.3 [5.1, 8.4]

0.271

0.728

0.738

 Hb, g/dL

13.0 ± 1.9

13.0 ± 1.9

13.0 ± 2.0

0.524

0.812

0.856

 Platelet, /μL*1000

262 ± 99

274 ± 96

268 ± 99

0.101

0.547

0.624

 Albumin, g/dL

4.1 [3.6, 4.4]

4.1 [3.8, 4.4]

4.1 [3.7, 4.4]

0.456

0.984

0.672

 Protein, g/dL

7.2 [6.8, 7.6]

7.2 [6.9, 7.7]

7.1 [6.8, 7.7]

0.150

0.906

0.254

 AST, U/L

25 [19, 31]

25 [19, 32]

24 [20, 37]

0.323

0.156

0.412

 ALT, U/L

18 [12, 26.5]

18 [13, 26]

18 [13, 34]

0.756

0.195

0.268

Radiographic

 Cavity

30 (8.3%)

43 (9.7%)

9 (7.7%)

0.574

0.986

0.625

Adverse events

 Any

60 (16.6%)

86 (19.4%)

30 (25.6%)

0.353

0.042

0.177

 Hepatotoxicity

16 (4.4%)

24 (5.4%)

19 (16.2%)

0.634

 < 0.001

 < 0.001

 Skin rash

8 (2.2%)

24 (5.4%)

4 (3.4%)

0.033

0.702

0.520

 GI trouble

18 (5.0%)

29 (6.5%)

11 (9.4%)

0.431

0.130

0.387

 CBC abnormalities

6 (1.7%)

6 (1.4%)

1 (0.9%)

0.948

0.850

 > 0.999

 Fever

0 (0%)

4 (0.9%)

1 (0.9%)

0.192

0.552

 > 0.999

 Arthralgia

8 (2.2%)

8 (1.8%)

1 (0.9%)

0.873

0.582

0.753

 Neuropathy

6 (1.7%)

1 (0.2%)

1 (0.9%)

0.072

0.850

0.886

  1. Abbreviations: TB Tuberculosis, NTM Non-tuberculosis mycobacterium, LTBI Latent tuberculosis infection, BMI Body mass index, COPD Chronic obstructive pulmonary disease, HTN Hypertension, BPH Benign prostate hyperplasia, WBC White blood cell count, Hb Hemoglobin, BUN Blood urea nitrogen, Cr Creatinine, AST Aspartate aminotransferase, ALT Alkaline aminotransferase, CBC Complete blood count
Back to article page

BMC Pulmonary Medicine

ISSN: 1471-2466

Contact us