Fig. 5
From: Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
Effects of metformin and ferroptosis inhibitor ferrostatin-1 (Fer-1) on the ferroptosis-related mRNA and protein expression. (A-C), the mRNA and protein expression levels of Gpx4 and SLC7A11 in A549 and H1299 lung cancer cells treated with metformin and/or Fer-1 for 48 h; (D-F), the mRNA and protein expression levels of Nrf2 and HO-1 in A549 and H1299 lung cancer cells treated with metformin and/or Fer-1 for 48 h. *P < 0.05 compared with the control group