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Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension through the PHD2/HIF1α signaling pathway

Fig. 1

AS-IV attenuated PAH progression in PAH model rats. A, Schematic diagram displaying in vivo experiments procedures. B, Pathological changes of pulmonary artery in indicated rats was observed by hematoxylin-eosin staining. Scale bar = 100 μm. C-D, Pulmonary vessel area and wall thickness of pulmonary artery were measured. E, Analysis of mPAP in indicated rats. F, Weight ratio of the right ventricle to the left ventricle and the septum [RV/(LV + S)] was calculated. *P<0.05, **P<0.01, ***P<0.001, comparison with NC group. #P<0.05, ##P<0.01, ###P<0.001, comparison with PAH group

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BMC Pulmonary Medicine

ISSN: 1471-2466

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