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Fig. 4 | BMC Pulmonary Medicine

Fig. 4

From: Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension through the PHD2/HIF1α signaling pathway

Fig. 4

AS-IV affected the PHD2-HIF1α axis in PAH model rats and hypoxia-treated PASMCs. A-B, Immunofluorescence staining of PHD2 and HIF1α in pulmonary artery tissue section of the above rats. Scale bar = 50 μm. C-D, Quantification of PHD2 and HIF1α density in pulmonary tissues. ***P<0.001, comparison with NC group. ###P<0.001, comparison with PAH group. E, Cropped blots of PHD2 and HIF1α in above PASMCs and quantification of grayscale value (the samples derived from the same experiment and that gels/blots were processed in parallel). **P<0.01, ***P<0.001, comparison with Nor group.##P<0.01, ###P<0.001, comparison with Hyp group

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BMC Pulmonary Medicine

ISSN: 1471-2466

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