Fig. 6From: Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension through the PHD2/HIF1α signaling pathwayMechanism’s diagram. AS-IV elevates PHD2 expression to accelerate HIF1α degradation, and then suppresses NLRP3-mediated pyroptosis and MMPs/TIMPs-mediated fibrosis development in hypoxia-induced PASMCs, thus restraining PAH progressionBack to article page