Fig. 2

PEDF inhibited inflammatory injury and cell apoptosis in rat lung tissue. A H&E-stained cross-section of the lung from LPS-exposed rats with or without PEDF treatment. Scale bars: 200 μm. n = 5. B The pathological scores of each group. n = 5. C Quantitative analysis of lung W/D ratio. Quantification of cytokines. D TNF-α, E IL-6, and F IL-1β expression levels. G Quantitative analysis of lung tissue MPO activity and H the number of neutrophils. I Representative images of TUNEL staining of lung tissue. Scale bars: 200 μm. Images are representative of five animals. J Quantitative analysis of lung tissue apoptosis. n = 5, Data are expressed as the mean ± SD, *P < 0.05; **P < 0.01 vs. LPS group