Fig. 4

PEDF reduces LPS-induced inflammatory damage and cytokines. A Immunoblot analysis of NLRP3, p38 MAPK, phospho-p38 MAPK, NF-κB p65 and phospho-NF-κB p65. B, C and D Quantification of the related protein expression. n = 4, Data are expressed as the mean ± SD, *P < 0.05. Quantification of cytokine concentrations in the cell supernatant. E TNF-α, F IL-6, and G IL-1β expression levels. Data are expressed as the mean ± SD, n = 4, *P < 0.05; **P < 0.01 vs. LPS group