Fig. 2
Elevated iron deposition and overactive ferroptosis in lungs from BPD rats. A Establishment of a rat BPD model. B Relative Fe2+ level in lungs of BPD and control rats. C Relative MDA level in lungs of BPD and control rats. D Relative mRNA expression level of ferroptosis-related genes in lungs of BPD rats and control rats. MDA, malondialdehyde, ACSL4, acyl-CoA synthase long-chain family member 4. HMOX1, heme oxygenase 1. FTH, ferritin heavy chain. ATM, ataxia telangiectasia mutated. ATF3, activating transcription factor 3. PRKAA1, protein kinase AMP-activated catalytic submit alpha-1. GSS, Glutathione. All data throughout the figure was presented as mean ± SEM (n ≥ 7). Statistical comparison by unpaired t-test, * p < 0.05, ** p < 0.01