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Table 2 Cox survival analysis in the ≤ 6 months group

From: The diagnosis interval influences risk factors of mortality in patients with co-existent active tuberculosis and lung cancer: a retrospective study

Variable

Univariate Analysis

Multivariate Analysis

HR (95%CI)

P Value

HR (95%CI)

P Value

Gender(male)

2.550(0.745–8.730)

0.136

  

Age, y (≥ 65)

0.294(0.114–0.760)

0.011

0.237(0.016–3.591)

0.299

Tumor location

 

0.125

  

 Bilateral

Reference

   

 Right

0.386(0.123–1.207)

0.102

  

 Left

0.271(0.075–0.973)

0.045

  

Cancer type

 

0.627

  

 SCLC

Reference

   

 Adenocarcinoma

1.037(0.132–8.161)

0.973

  

 Squamous-cell carcinoma

1.818(0.232–14.255)

0.569

  

Stage

 

0.320

  

 I

Reference

   

 II

N/A

0.999

  

 III

N/A

0.915

  

 IV

N/A

0.906

  

 Unknown

N/A

0.910

  

Smoking

3.519(1.267–9.774)

0.016

0.462(0.038–5.568)

0.544

System involved

 

0.870

  

 Pulmonary only

Reference

   

 Extrapulmonary only

1.182(0.158–8.821)

   

Tuberculosis retreatment

 

0.977

  

 No

Reference

   

 Yes

1.031(0.135–7.843)

   

Anti-PD-(L)1 therapy

 

0.579

  

 No

Reference

   

 Yes

0.037(N/A)

   

 Surgery

0.077(0.010–0.577)

0.013

0.000(N/A)

0.946

ECOG Performance Status

 

 < 0.001

 

0.081

 0–2

Reference

 

Reference

 

 3–4

16.329(6.598–40.415)

 

12.619(0.732–217.420)

 

Chemotherapy

 

0.268

  

 No

Reference

   

 Yes

0.542(0.183–1.603)

   

Targeted therapy

 

0.313

  

 No

Reference

   

 Yes

0.355(0.048–2.649)

   

Radiotherapy

 

0.739

  

 No

Reference

   

 Yes

1.231(0.362–3.190)

   

CRP(mg/L),n (%)

 

0.083

  

  < 10

Reference

   

 10–50

10.397(1.288–83.951)

0.028

  

  > 50

2.598(0.463–14.587)

0.278

  

IL-1β

 

0.969

  

 Normal

Reference

   

 Higher than normal

0.968(0.187–5.017)

   

IL-2R

 

0.039

 

0.947

 Normal

Reference

 

Reference

 

 Higher than normal

9.376(1.122–78.323)

 

1293597.415(N/A)

 

IL-6

 

0.179

  

 Normal

Reference

   

 Higher than normal

4.305(0.512–36.198)

   

TNF-α

 

0.564

  

 Normal

Reference

   

 Higher than normal

25.642(N/A)

   

IGRA

 

0.917

  

 Negative

Reference

   

 Positive

0.936(0.273–3.211)

   

Cavity

 

0.100

  

 No

Reference

   

 Yes

2.096(0.867–5.065)

   
  1. Abbreviations: SCLC small-cell lung cancer, ECOG Eastern Cooperative Oncology Group, CRP C-reactive protein, IL interleukin, TNF tumor necrosis factor, IGRA interferon gamma release assay, HR hazard ratio, CI confidence interval
  2. A p-value of less than 0.05 represents a significant statistical difference
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BMC Pulmonary Medicine

ISSN: 1471-2466

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