Variable | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|
HR (95%CI) | P Value | HR (95%CI) | P Value | |
Gender(male) | 5.540(0.712–43.083) | 0.102 |  |  |
Age, y (≥ 65) | 1.464(0.492–4.357) | 0.494 |  |  |
Tumor location | Â | 0.701 | Â | Â |
 Bilateral | Reference |  |  |  |
 Right | 1.256(0.154–10.279) | 0.832 |  |  |
 Left | 0.765(0.075–0.973) | 0.807 |  |  |
Cancer type | Â | 0.987 | Â | Â |
 SCLC | Reference |  |  |  |
 Adenocarcinoma | N/A | 0.947 |  |  |
 Squamous-cell carcinoma | N/A | 0.945 |  |  |
Stage | Â | 0.067 | Â | Â |
 I | Reference |  |  |  |
 II | N/A | 0.987 |  |  |
 III | 15.192(1.675–137.826) | 0.016 |  |  |
 IV | 12.715(1.556–103.866) | 0.018 |  |  |
 Unknown | 2.047(0.128–32.788) | 0.613 |  |  |
Smoking | 3.525(0.768–16.179) | 0.105 |  |  |
System involved | Â | 0.636 | Â | Â |
 Pulmonary only | Reference |  |  |  |
 Extrapulmonary only | N/A | 0.669 |  |  |
 Pulmonary and extrapulmonary | N/A | 0.395 |  |  |
Tuberculosis retreatment | Â | 0.509 | Â | Â |
 No | Reference |  |  |  |
 Yes | 0.502(0.065–3.872) |  |  |  |
Anti-PD-(L)1 therapy | Â | 0.731 | Â | Â |
 No | Reference |  |  |  |
 Yes | 1.430(0.186–11.010) |  |  |  |
 Surgery | 0.079(0.021–0.296) |  < 0.001 | 0.193(0.038–0.970) | 0.046 |
ECOG Performance Status |  |  < 0.001 | 12.866(2.730–60.638) | 0.001 |
 0–2 | Reference |  |  |  |
 3–5 | 39.118(9.852–155.313) |  |  |  |
Chemotherapy | Â | 0.685 | Â | Â |
 No | Reference |  |  |  |
 Yes | 0.783(0.241–2.546) |  |  |  |
Targeted therapy |  | 0.859 |  |  |
 No | Reference |  |  |  |
 Yes | 0.872(0.192–3.968) |  |  |  |
Radiotherapy | Â | 0.444 | Â | Â |
 No | Reference |  |  |  |
 Yes | 0.450(0.058–3.470) |  |  |  |
CRP(mg/L),n (%) | Â | 0.112 | Â | Â |
  < 10 | Reference |  |  |  |
 10–50 | 6.762(0.598–76.462) | 0.122 |  |  |
  > 50 | 11.485(1.165–113.215) | 0.037 |  |  |
IL-1β |  | 0.506 |  |  |
 Normal | Reference |  |  |  |
 Higher than normal | 0.488(0.059–4.060) |  |  |  |
IL-2R | Â | 0.185 | Â | Â |
 Normal | Reference |  |  |  |
 Higher than normal | 4.202(0.503–35.074) |  |  |  |
IL-6 | Â | 0.312 | Â | 0.967 |
 Normal | Reference |  | Reference |  |
 Higher than normal | 35.307(N/A) |  | N/A |  |
TNF-α |  | 0.854 |  |  |
 Normal | Reference |  |  |  |
 Higher than normal | 1.230(0.135–11.173) |  |  |  |
IGRA | Â | 0.813 | Â | Â |
 Negative | Reference |  |  |  |
 Positive | 1.286(0.159–10.383) |  |  |  |
Cavity | Â | 0.517 | Â | Â |
 No | Reference |  |  |  |
 Yes | 1.927(0.629–5.903) | 0.251 |  |  |