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Table 3 Cox survival analysis in the > 6 months group

From: The diagnosis interval influences risk factors of mortality in patients with co-existent active tuberculosis and lung cancer: a retrospective study

Variable

Univariate Analysis

Multivariate Analysis

HR (95%CI)

P Value

HR (95%CI)

P Value

Gender(male)

5.540(0.712–43.083)

0.102

  

Age, y (≥ 65)

1.464(0.492–4.357)

0.494

  

Tumor location

 

0.701

  

 Bilateral

Reference

   

 Right

1.256(0.154–10.279)

0.832

  

 Left

0.765(0.075–0.973)

0.807

  

Cancer type

 

0.987

  

 SCLC

Reference

   

 Adenocarcinoma

N/A

0.947

  

 Squamous-cell carcinoma

N/A

0.945

  

Stage

 

0.067

  

 I

Reference

   

 II

N/A

0.987

  

 III

15.192(1.675–137.826)

0.016

  

 IV

12.715(1.556–103.866)

0.018

  

 Unknown

2.047(0.128–32.788)

0.613

  

Smoking

3.525(0.768–16.179)

0.105

  

System involved

 

0.636

  

 Pulmonary only

Reference

   

 Extrapulmonary only

N/A

0.669

  

 Pulmonary and extrapulmonary

N/A

0.395

  

Tuberculosis retreatment

 

0.509

  

 No

Reference

   

 Yes

0.502(0.065–3.872)

   

Anti-PD-(L)1 therapy

 

0.731

  

 No

Reference

   

 Yes

1.430(0.186–11.010)

   

 Surgery

0.079(0.021–0.296)

 < 0.001

0.193(0.038–0.970)

0.046

ECOG Performance Status

 

 < 0.001

12.866(2.730–60.638)

0.001

 0–2

Reference

   

 3–5

39.118(9.852–155.313)

   

Chemotherapy

 

0.685

  

 No

Reference

   

 Yes

0.783(0.241–2.546)

   

Targeted therapy

 

0.859

  

 No

Reference

   

 Yes

0.872(0.192–3.968)

   

Radiotherapy

 

0.444

  

 No

Reference

   

 Yes

0.450(0.058–3.470)

   

CRP(mg/L),n (%)

 

0.112

  

  < 10

Reference

   

 10–50

6.762(0.598–76.462)

0.122

  

  > 50

11.485(1.165–113.215)

0.037

  

IL-1β

 

0.506

  

 Normal

Reference

   

 Higher than normal

0.488(0.059–4.060)

   

IL-2R

 

0.185

  

 Normal

Reference

   

 Higher than normal

4.202(0.503–35.074)

   

IL-6

 

0.312

 

0.967

 Normal

Reference

 

Reference

 

 Higher than normal

35.307(N/A)

 

N/A

 

TNF-α

 

0.854

  

 Normal

Reference

   

 Higher than normal

1.230(0.135–11.173)

   

IGRA

 

0.813

  

 Negative

Reference

   

 Positive

1.286(0.159–10.383)

   

Cavity

 

0.517

  

 No

Reference

   

 Yes

1.927(0.629–5.903)

0.251

  
  1. Abbreviations: SCLC small-cell lung cancer, ECOG Eastern Cooperative Oncology Group, CRP C-reactive protein, IL interleukin, TNF tumor necrosis factor, IGRA interferon gamma release assay, HR hazard ratio, CI confidence interval. A p-value of less than 0.05 represents a significant statistical difference