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Table 2 Associations between CASA-Q, and clinical, functional, microbiological and radiological data

From: Current cough and sputum assessed by the cough and sputum assessment-questionnaire (CASA-Q) is associated with quality of life impairment in cystic fibrosis

 

CASA-Q

 

Cough

Symptoms

Cough

Impact

Sputum

Symptoms

Sputum

Impact

Gender

0.029

0.014

0.167

0.061

Age, years

− 0.208; 0.15

− 0.206; 0.159

− 0.224; 0.125

− 0.209; 0.154

BMI, kg/m²

0.123; 0.430

0.025; 0.825

0.088; 0.552

-0.037; 0.803

Smoker

0.649

0.181

0.488

0.076

 Ex

0.848

0.894

0.766

0.781

 Pack-years

0.312; 0.688

0.044; 0.956

0.525; 0.475

0.171; 0.829

CFTR mutation°

0.197

0.061

0.051

0.008

Pancreatic insufficiency

0.644

0.63

0.618

0.229

Diabetes

0.441

0.843

0.517

0.860

Osteoporosis

0.493

0.714

0.785

0.967

Dyspnea (mMRC > 2)

0.002

< 0.001

0.002

0.001

Exacerbation in the last year

0.030

0,105

0.010

0.36

 Number of episodes/patient

-0.144; 0.33

− 0.169; 0.252

-0.28; 0.054

-0.183; 0.213

FEV1,% predicted

0.205; 0.162

0.001; 0.994

0.154; 0.296

-0.097; 0.511

6-minute walking test#

    

 Distance, m

0.396; 0.061

0.521; 0.011

0.294; 0.173

0.526; 0.010

 Distance, % predicted

0.31; 0.15

0.461; 0.027

0.153; 0.486

0.456; 0.029

Chronic colonisation by SA

0.498

0.349

0.647

0.913

Chronic colonisation by PA

0.358

0.923

0.131

0.784

SA in sputum at inclusion*

0.751

0.203

0.356

0.292

PA in sputum at inclusion*

0.512

0.316

0.373

0.523

CT-scan score

0.115; 0.695

0.174; 0.551

0.251; 0.387

0.362; 0.204

  1. Data are expressed as “p-value” for qualitative variables and “r²; p-value” for quantitative variables
  2. BMI: body mass index; m: meters; CASA-Q: Cough and sputum assessment questionnaire; FEV1: forced expiratory volume; SA: Staphylococcus aureus; PA: Pseudomonas aeruginosa
  3. ° homozygote vs. heterozogote
  4. # data missing for n = 25 patients
  5. * data missing for n = 8 patients
  6. data missing for n = 14 patients