Fig. 2From: Causal associations between hand grip strength and pulmonary function: a two-sample Mendelian randomization studyThree key assumptions of the MR study. (i) SNPs are robustly associated with HGS (hand grip strength); (ii) SNPs are independent of other known confounders; (iii) SNPs affect the risk of PF (pulmonary function) only through HGS. The red X means that the SNPs selected as the instrumental variables are not associated with the confounders and the outcomes directly.Back to article page