Table 1 Mendelian randomization estimates between right-hand grip strength and pulmonary function
Outcomes | SNP selection | No. of SNPs | IVW | MR Egger | Weighted median | Simple mode | Weighted mode | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | |||
FVC | All | 169 | 1.987 | 2.31E-60 | 1.742 | 2.71E-04 | 1.622 | 4.42E-63 | 1.760 | 4.43E-14 | 1.697 | 1.98E-10 |
(1.830-2.157) | (1.300-2.333) | (1.533-1.717) | (1.539-2.013) | (1.457-1.978) | ||||||||
Remove | 104 | 1.519 | 8.96E-33 | 1.410 | 8.86E-03 | 1.480 | 5.61E-35 | 1.729 | 1.03E-08 | 1.692 | 1.43E-02 | |
(1.418-1.627) | (1.095-1.814) | (1.390-1.575) | (1.456-2.055) | (1.119-2.559) | ||||||||
FEV1 | All | 169 | 1.839 | 2.03E-58 | 1.411 | 1.06E-02 | 1.562 | 1.28E-50 | 1.641 | 1.75E-06 | 1.504 | 5.19E-06 |
(1.707-1.980) | (1.087-1.831) | (1.473-1.656) | 1.349-1.996) | (1.269-1.782) | ||||||||
Remove | 104 | 1.486 | 3.19E-31 | 1.266 | 6.05E-0 | 1.379 | 5.69E-22 | 1.690 | 5.30E-06 | 1.352 | 3.64E-02 | |
(1.390-1.589) | (0.992-1.615) | (1.292-1.472) | (1.365-2.095) | (1.023-1.786) | ||||||||
FEV1/FVC | All | 165 | 0.938 | 2.60E-01 | 0.670 | 4.90E-02 | 0.985 | 6.58E-01 | 0.990 | 9.31E-01 | 1.003 | 9.78E-01 |
(0.839-1.049) | (0.451-0.995) | (0.919-1.055) | (0.792-1.237) | (0.820-1.226) | ||||||||
0.998 | 0.852 | 1.048 | 1.025 | 1.035 | ||||||||
Remove | 101 | (0.902-1.103) | 9.62E-01 | (0.589-1.232) | 3.96E-01 | (0.962-1.142) | 2.85E-01 | (0.801-1.312) | 8.46E-01 | (0.848-1.263) | 7.36E-01 | |