Table 3 Mendelian randomization estimates between left-hand grip strength and pulmonary function
Outcomes | SNP selection | No. of SNPs | IVW | MR Egger | Weighted median | Simple mode | Weighted mode | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | |||
FVC | All | 155 | 1.907 | 1.05E-62 | 2.257 | 3.74E-07 | 1.604 | 1.05E-62 | 1.633 | 7.05E-11 | 1.622 | 1.05E-08 |
(1.759-2.068) | (1.672-3.048) | (1.518-1.695) | (1.424-1.873) | (1.387-1.897) | ||||||||
Remove | 103 | 1.464 | 2.83E-41 | 1.239 | 4.33E-02 | 1.501 | 4.35E-41 | 1.622 | 1.84E-09 | 1.629 | 8.07E-07 | |
(1.385-1.548) | (1.009-1.521) | (1.414-1.592) | (1.405-1.872) | (1.358-1.953) | ||||||||
FEV1 | All | 155 | 1.773 | 1.52E-49 | 1.875 | 2.31E-05 | 1.534 | 9.77E-49 | 1.591 | 6.40E-07 | 1.557 | 9.10E-06 |
(1.643-1.912) | (1.414-2.486) | (1.449-1.624) | (1.335-1.896) | (1.289-1.881) | ||||||||
Remove | 103 | 1.486 | 3.19E-33 | 1.235 | 5.36E-02 | 1.419 | 7.03E-30 | 1.586 | 1.57E-06 | 1.586 | 2.60E-03 | |
(1.340-1.502) | (0.999-1.527) | (1.336-1.507) | (1.328-1.893) | (1.183-2.125) | ||||||||
FEV1/FVC | All | 152 | 0.938 | 2.66E-01 | 0.796 | 3.17E-01 | 0.978 | 5.48E-01 | 0.913 | 2.66E-01 | 0.966 | 7.14E-01 |
(0.830-1.053) | (0.150-1.242) | (0.910-1.051) | (0.746-1.117) | (0.801-1.164) | ||||||||
0.998 | 1.254 | 0.984 | 0.840 | 0.921 | ||||||||
Remove | 101 | (0.861-1.083) | 5.52E-01 | (0.815-1.930) | 3.06E-01 | (0.901-1.075) | 7.27E-01 | (0.652-1.083) | 1.81E-01 | (0.722-1.175) | 5.11E-01 | |