Table 1 Characteristics of 9 included studies in this meta-analysis
Study | Duration | N | Treatment cycle, weeks | Follow-up, months | Group | n, M/F | Age, years | Course of disease, months | Dose |
|---|---|---|---|---|---|---|---|---|---|
Chen, JC 2016 [24] | 2013.02-2015.01 | 160 | 12 | 6 | Mon+Flu | 80, 43/37 | 6.3±0.7 | 4.7±0.5 | Flu group + 4-5 mg/day |
|  |  |  |  | Flu | 80, 41/39 | 6.5±0.9 | 4.8±0.8 | 2 times/day, 125 μg/time | |
Dong, JJ 2020 [25] | 2016.06-2018.06 | 70 | 12 | 3 | Mon+Flu | 35, 20/15 | 6.8±1.8 | 6.0±2.2 | Flu group + 4-5 mg/day |
|  |  |  |  | Flu | 35, 20/15 | 6.6±1.2 | 5.4±1.5 | 2 times/day, 125 μg/time | |
Hu, HJ 2021 [26] | 2017.01-2019.12 | 100 | 12 | NR | Mon+Flu | 50, 27/23 | 7.1±2.2 | 2.08±0.60 | Flu group + 4 mg/day |
|  |  |  |  | Flu | 50, 27/23 | 7.5±2.4 | 2.18±0.62 | 2 times/day, 125 μg/time | |
Lai, M 2021 [14] | 2017.07-2020.01 | 64 | 8 | NR | Mon+Flu | 32, 19/13 | 8.97±2.54 | 3.68±0.74 | Flu group + 5 mg/day |
|  |  |  |  | Flu | 32, 16/16 | 9.10±2.17 | 3.66±0.81 | 2 times/day, 125 μg/time | |
Li, RX 2018 [27] | 2016.01-2016.12 | 97 | 12 | 6 | Mon+Flu | 49, 29/20 | 8.92±1.07 | 10.32±4.56 | Flu group + 4-5 mg/day |
|  |  |  |  | Flu | 48, 30/18 | 9.11±0.87 | 9.79±5.02 | 2 times/day, 125 μg/time | |
Wu, JH 2011 [28] | 2004.07-2008.01 | 85 | 12 | 6 | Mon+Flu | 43, 23/20 | 6.2±3.6 | 2.47±1.26 | Flu group + 4-5 mg/day |
|  |  |  |  | Flu | 42, 23/19 | 5.8±4.3 | 2.66±1.18 | 1-2 times/day, 125 μg/time | |
Xu, QR 2018 [15] | 2013.06-2016.01 | 180 | 8 | NR | Mon+Flu | 90, 47/43 | 10.38±2.25 | NR | Flu group + 5 mg/day |
|  |  |  |  | Flu | 90, 42/48 | 12.00±1.74 | NR | 2 times/day, 125 μg/time | |
Zeng, JZ 2016 [23] | 2014.03-2016.03 | 90 | 24 | NR | Mon+Flu | 45, 27/18 | 5.9±0.3 | 12.4±3.3 | Flu group + 10 mg/day |
|  |  |  |  | Flu | 45, 26/19 | 5.6±0.5 | 13.2±3.7 | 2 times/day, 250 μg/time | |
Zhu, XH 2019 [22] | 2015.06-2018.01 | 80 | 12 | 3 | Mon+Flu | 40, 19/21 | 5.9±0.9 | 5.4±0.5 | Flu group + 4-5 mg/day |
|  |  |  |  | Flu | 40, 21/19 | 6.0±0.9 | 5.3±0.7 | 2 times/day, 125 μg/time |