Table 4 Variables predicting acute exacerbation and overall survival

Univariate Cox regression

Phenotypic cluster^a

< 0.001

Cluster 1

2.38

1.53–3.70

< 0.001

4.06

2.10–7.86

< 0.001

Cluster 3

1.80

1.10–2.95

0.019

5.78

2.99–11.18

< 0.001

Cluster 4

0.76

0.40–1.45

0.405

1.61

0.71–3.67

0.255

Diagnosis category^b

< 0.001

CTD-ILD

0.93

0.61–1.43

0.743

0.41

0.27–0.62

< 0.001

iNSIP

8.45

2.00-35.66

0.004

2.75

0.38–20.11

0.319

FHP

0.38

0.15–0.98

0.045

0.28

0.11–0.7

0.007

uIIP

0.89

0.43–1.84

0.756

0.29

0.12–0.74

0.010

Occupational related ILDs

0.43

0.23–0.78

0.006

0.15

0.08–0.32

< 0.001

Sarcoidosis

0.00

0

0.957

0.00

0

0.950

GAP score

1.33

1.18–1.50

< 0.001

1.47

1.29–1.69

< 0.001

Multivariable Cox regression^c

Phenotypic cluster^a

< 0.001

Cluster 1

2.29

1.43–3.68

0.001

3.99

1.98–8.05

< 0.001

Cluster 3

1.21

0.65–2.27

0.546

2.90

1.31–6.41

0.008

Cluster 4

0.89

0.44–1.79

0.741

2.03

0.84–4.92

0.116

GAP score

1.31

1.16–1.48

< 0.001

1.34

1.17–1.54

< 0.001