Table 1 Clinical and laboratory characteristics of patients with POEMS syndrome
From: Pulmonary manifestations of POEM syndrome: a retrospective analysis of 282 cases
ALL | male | female | |
|---|---|---|---|
N, (%) | 282 (100.0) | 158 (56.0) | 124 (44.0) |
Age, years | 48.7 ± 10.8 | 48.7 ± 11.6 | 48.6 ± 9.8 |
Smoking, N (%) | 71 (25.2) | 70 (44.3) | 1 (0.8) |
Alcohol, N (%) | 40 (14.2) | 39 (24.7) | 1 (0.8) |
Respiratory symptoms | |||
Dyspnea, N (%) | 97 (34.4) | 29 (18.4) | 32 (25.8) |
Chest tightness, N (%) | 61 (21.6) | 47 (29.7) | 50 (40.3) |
Orthopnea, N (%) | 46 (16.3) | 15 (9.5) | 31 (25) |
Cough, N (%) | 15 (5.3) | 8 (5.1) | 7 (5.6) |
Comorbidities | |||
Hypertension, N (%) | 78 (27.7) | 43 (27.2) | 35 (28.2) |
Cardiac disease, N (%) | 14 (5) | 12 (7.6) | 2 (1.6) |
Diabetes, N (%) | 37 (13.1) | 25 (15.8) | 12 (9.7) |
Cancer, N (%) | 5 (1.8) | 2 (1.3) | 3 (2.4) |
POEMS manifestations | |||
Polyneuropathy, N (%) | 264 (93.6) | 148 (93.7) | 116 (93.5) |
Organomegaly, N (%) | 260 (92.2) | 141 (89.2) | 119 (96) |
Endocrinopathy, N (%) | 246 (87.2) | 145 (91.8) | 101 (81.5) |
Monoclonal gammopathy, N (%) | 245 (86.9) | 135 (85.4) | 110 (88.7) |
Skin changes, N% | 245 (86.9) | 138 (87.3) | 107 (86.3) |
Bone lesions, N (%) | 158 (56) | 100 (63.3) | 58 (46.8) |
Peripheral oedema, N (%) | 218 (77.3) | 117 (74.1) | 101 (81.5) |
Papilledema, N (%) | 100 (35.5) | 49 (31) | 51 (41.1) |
Castleman disease, N (%) | 41 (14.5) | 14 (8.9) | 27 (21.8) |
Laboratory test results | |||
Albumin, g/L | 35.1 ± 5.8 | 35.2 ± 6.0 | 35.0 ± 5.7 |
LDH, U/L | 133.5 ± 43.8 | 139.5 ± 50.7 | 125.9 ± 31.7 |
IL-6, pg/mL | 6.2 (3.5–13.1) | 6.2 (3.4–11.8) | 6.65 (3.6–13.8) |
TNF-α, pg/mL | 13.9 (10.4–20.6) | 15.4 (11.1–21.1) | 11.8 (9.6–20.5) |
C3, g/L | 0.9 ± 0.2 | 0.9 ± 0.2 | 1.0 ± 0.2 |
C4, g/L | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
β-CTX, ng/ml | 1.2 (0.8–1.7) | 1.2 (0.8–1.8) | 1.1 (0.8–1.6) |
KAP, % | 7 (2.5) | 4 (2.5) | 3 (2.4) |
LAM, % | 235 (83.3) | 130 (82.3) | 105 (84.7) |
VEGF > 1200 pg/mL, % | 241 (85.5) | 133 (84.2) | 108 (87.1) |
Duration of diagnosis, years | 1.3 (0.6–2) | 1.2 (0.6–2.0) | 1.3 (0.6–2) |
Length of stay, days | 10.0 (4.0–21.3) | 9.0 (4.0–21.0) | 12.5 (5.0–23.0) |