Table 4 Relationship between pulmonary manifestations and the severity of POEMS syndrome
From: Pulmonary manifestations of POEM syndrome: a retrospective analysis of 282 cases
Low risk | Intermediate risk | High risk | Adjusted P-valuea | |
|---|---|---|---|---|
Mediastinal or hilar lymphadenopathy, N (%) | 28 (51.9) | 55 (59.8) | 94 (69.1) | 0.052 |
Pleural thickening, N (%) | 25 (46.3) | 46 (50.0) | 60 (44.1) | 0.497 |
Rib or thoracic vertebral bone lesions, N (%) | 20 (37.0) | 24 (26.1) | 33 (24.3) | 0.088 |
Interstitial lung disease, N (%) | 2 (3.7) | 6 (6.5) | 14 (10.3) | 0.698 |
Heart enlargement, N (%) | 10 (18.5) | 35 (38.0) | 69 (50.7) | 0.012 |
Pericardial effusions, N (%) | 27 (50.0) | 62 (67.4) | 121 (89.0) | < 0.001 |
Systolic dysfunction, N (%) | 0 (0.0) | 1 (1.1) | 1 (4.4) | 0.065 |
Diastolic dysfunction, N (%) | 18 (33.3) | 36 (39.1) | 54 (39.7) | 0.291 |
PFT | ||||
FEV1, L | 3.02 ± 0.50 | 2.51 ± 0.58 | 1.79 ± 0.60 | < 0.001 |
FEV1% of predicted | 95.79 ± 14.56 | 85.79 ± 16.79 | 69.89 ± 19. 07 | < 0.001 |
FVC, L | 3.69 ± 0.63 | 3.11 ± 0.74 | 2.30 ± 0.78 | < 0.001 |
FVC% of predicted | 97.08 ± 16.53 | 84.64 ± 20.08 | 72.43 ± 20.26 | < 0.001 |
DLCO% of predicted | 78.52 ± 18.96 | 68.04 ± 17.17 | 48.27 ± 20.26 | < 0.001 |
TLC% of predicted | 88.50 ± 12.11 | 81.61 ± 11.70 | 76.81 ± 15.98 | < 0.001 |
Diffuse dysfunction, N (%) | 27 (77.1) | 45 (84.9) | 43 (91.5) | 0.013 |
Restrictive dysfunction, N (%) | 10 (28.6) | 23 (43.4) | 31 (66.0) | < 0.001 |
Obstructive dysfunction, N (%) | 3 (8.6) | 7 (13.2) | 13 (27.1) | 0.001 |