Fig. 4

A 45-year-old man with a mass shadow on the left B¹⁺² and bronchoscopic luminal findings showed an image of the left B¹⁺² lm being extramural and compressed. Radial EBUS probe showed an image of a probe inserted into the tumor (within). TBBs were performed, the first to fourth TBBs showed malignant cells in the ROSE ([+] means tumor cell was detected), but the histopathological analysis revealed that tissue specimens did not contain tumor cells; after the fourth biopsy, transbronchial needle biopsy was performed, and the fifth and subsequent biopsies were successful in collecting tissue specimens with a tumor content of more than 80%. Next-generation sequencing analysis detected EML4-ALK fusion.Original Article