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Table 3 Relationship between early (0–10 days) changes in lymphocyte count (109/L) and death in COVID-19 patients (from GAMM)

From: Early decrease in blood lymphocyte count is associated with poor prognosis in COVID-19 patients: a retrospective cohort study

Outcome

Model I

Model II

 

β (95%CI)

P-value

β (95%CI)

P-value

Intercept

1.5131 (1.3451, 1.6811)

< 0.0001

0.4872 (0.3185, 0.6559)

< 0.0001

Day

0.0633 (0.0553, 0.0714)

< 0.0001

0.0632 (0.0553, 0.0710)

< 0.0001

Death

−0.1073 (−0.3330, 0.1183)

0.3516

0.1077 (−0.0733, 0.2886)

0.2440

Day×Death

−0.0732 (− 0.1040, − 0.0424)

< 0.0001

−0.0731 (− 0.1028, − 0.0434)

< 0.0001

  1. β: the effect value of lymphocyte count over time; CI: confidence interval; Intercept: lymphocyte count at day = 0 and death = 0 (lymphocyte count at admission in the survival group); Day: the increasing value of lymphocyte count at death = 0 over time (changes in survival group lymphocyte count with length of hospital stay); Death: the difference of lymphocyte count at day = 0 between the group of death = 1 and the group of death = 0 (differences in lymphocyte counts between the surviving and non-surviving groups at admission); Day × death, the average increase in lymphocyte count daily under the condition of the group of death = 1 compared with the group of death = 0 (average difference in lymphocyte count changes between the surviving and non-surviving groups on a daily basis); Model I: adjusted for sex and age; Model II: adjusted for sex, age, white blood cell count, neutrophil count, lymphocyte count, history of hypertension, history of diabetes