Fig. 1

KLK8 expression in cancer and its correlation with survival. a KLK8 expression profiles in the tumor and paired normal tissues of pan-cancer types in TIMER. The height of the bar represents the median expression of certain tumor types or normal samples. Red, tumor; Blue, normal tissue. Yellow arrow, KLK8 expression in LUSC. ACC, Adrenocortical carcinoma; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast invasive carcinoma; CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, Cholangiocarcinoma; COAD, Colon adenocarcinoma; DLBC, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA, Esophageal carcinoma; GBM, Glioblastoma multiforme; HNSC, Head and Neck squamous cell carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; MESO, Malignant Mesothelioma; OV, Ovarian serous cystadenocarcinoma; PAAD, Pancreatic adenocarcinoma; PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate adenocarcinoma; READ, Rectum adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma; STAD, Stomach adenocarcinoma; TGCT, Testicular Germ Cell Tumors; THCA, Thyroid carcinoma; THYM, Thymoma; UCEC, Uterine Corpus Endometrial Carcinoma; USC, Uterine Carcinosarcoma. UVM, Uveal Melanoma. b KLK8 expression in LUAD and LUSC based on data in GEPIA. Left, LUAD. Right, LUSC. Red, tumor sample (T). Black, normal sample (N). Asterisk, p value< 0.05; Centerline, median; box limits, upper and lower quartiles; points, outliers. c-f K-M curve showing the overall survival of LUSC patients stratified by KLK8 expression in the TCGA LUSC data and GEO LUC datasets. Red, KLK8 low expression group. Green, KLK8 high expression group. TCGA LUSC data (c). GSE 73403 (d). GSE157011 (e). GSE30219 (f)