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Table 3 Multivariate Cox regression of prognostic factors in SqCLC

From: Tumor-derived KLK8 predicts inferior survival and promotes an immune-suppressive tumor microenvironment in lung squamous cell carcinoma

 

OS

HR (95%CI)

p-value

Tumor size

  

 ≤5

1.000

 

 > 5

1.42 (0.81–2.52)

0.228

T

  

 T1 + T2

1.000

 

 T3 + T4

1.89 (1.07–3.35)

0.027

N

  

 N0 + N1

1.000

 

 N2

2.38 (1.61–3.53)

< 0.001

CD47

  

 Low

1.000

 

 High

2.01 (1.21–3.32)

0.006

PDL1

  

 Low

1.000

 

 High

2.21 (0.63–7.74)

0.215

PDL1&CD47 expression

  

 Low

1.000

 

 High

0.66 (0.17–2.48)

0.542

CD8 expression

  

 Low

1.000

 

 High

0.49 (0.32–0.74)

< 0.001

PD1 expression

  

 Low

1.000

 

 High

1.47 (0.93–2.33)

0.094

TIGIT expression

  

 Low

1.000

 

 High

1.26 (0.82–1.98)

0.31

PVR expression

  

 Low

1.000

 

 High

2.05 (1.08–3.91)

0.027

KLK8 expression

  

 Low

1.000

 

 High

2.05 (1.37–3.06)

< 0.001

  1. All p values were two sides and less than 0.05 were considered significant. SqCLC Squamous cell lung cancer, OS overall survival, HR hazard ratio, CI confidence interval. Low and high expression was classified as the median except for CD47 (1% as cut-off value)