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Table 3 Predictors of poor response toward omalizumab and benralizumab

From: Factors influencing poor response to type 2 targeted therapies in severe asthma: a retrospective cohort study

Omalizumab

Factors

OR

95% CI

P

Age

0.98

(0.9279,1.0327)

0.434

BMI

0.99

(0.9101,1.0703)

0.743

 F-Sex

2.40

(0.5750,10.0029)

0.208

IHD

21.24

(2.7042,166.7854)

0.004

Bronchiectasis

7.02

(1.6755,29.3819)

0.008

Maintenance OCS

23.71

(2.8799,195.1335)

0.004

Benralizumab

Factors

OR

95% CI

P

Age

0.98

(0.9047,1.0686)

0.68

BMI

1.64

(0.9507,1.6530)

0.05

 F-Sex

7.32

(0.9900,54.2544)

0.03

Childhood onset asthma

7.17

(1.0984,46.8617)

0.02

FEV1% (< 60%)

2.94

(0.2621,33.1945)

0.36

  1. Logistic regression model with backward elimination, Goodness of fit test: Hosmer-Lemeshow, X2 = 11.16, P = 0.19, Coef: coefficient, OR: odd ratio, CI: confidence interval,P < 0.05 considered significant