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Table 3 Association between GAB1 gene variants and asthma risk

From: Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children

SNVs

Genotypes/

Alleles

Asthma

(n = 109)

Control

(n = 158)

pa

OR (95%CI)

pb

rs1396527

      
 

G/G

47(43.1)

85(53.8)

0.102

–

–

 

G/T

55(50.5)

59(37.3)

1.57(0.88–2.79)

0.125

 

T/T

7(6.4)

14(8.9)

0.78(0.27–2.31)

0.658

 

G

149(68.4)

229(72.5)

0.304

–

–

 

T

69(31.7)

87(27.5)

1.41(0.81–2.45)

0.222

rs17017425

      
 

T/T

55(50.5)

89(56.3)

0.573

–

–

 

T/C

47(43.1)

58(36.7)

1.08(0.61–1.92)

0.782

 

C/C

7(6.4)

11(7.0)

1.18(0.41–3.45)

0.760

 

T

157(72.0)

236(74.7)

0.492

–

–

 

C

61(28.0)

80(25.3)

1.10(0.64–1.89)

0.736

rs1866756

      
 

G/G

57(52.3)

92(58.2)

0.287

–

–

 

G/A

48(44.0)

56(35.4)

1.32(0.74–2.33)

0.346

 

A/A

4(3.7)

10(6.3)

0.64(0.17–2.35)

0.501

 

G

162(74.3)

240(76.0)

0.666

–

–

 

A

56(25.7)

76(24.1)

1.21(0.70–2.10)

0.503

rs3805236

      
 

A/A

54(49.5)

90(57.0)

0.248

–

–

 

A/G

48(44.0)

54(34.2)

1.42(0.79–2.54)

0.241

 

G/G

7(6.4)

14(8.9)

0.85(0.30–2.43)

0.761

 

A

156(71.6)

234(74.1)

0.524

–

–

 

G

62(28.4)

82(26.0)

1.30(0.75–2.26)

0.359

rs3805246

      
 

G/G

58(53.2)

92(58.2)

0.342

–

–

 

G/A

47(43.1)

56(35.4)

1.28(0.72–2.26)

0.401

 

A/A

4(3.7)

10(6.3)

0.63(0.17–2.32)

0.488

 

G

163(74.8)

240(76.0)

0.756

–

–

 

A

55(25.2)

76(24.1)

1.17(0.68–2.04)

0.568

rs3805254

      
 

A/A

58(53.2)

92(58.2)

0.342

–

–

 

A/G

47(43.1)

56(35.4)

1.28(0.72–2.26)

0.401

 

G/G

4(3.7)

10(6.3)

0.63(0.17–2.32)

0.488

 

A

163(74.8)

240(76.0)

0.756

–

–

 

G

55(25.2)

76(24.1)

1.17(0.68–2.04)

0.568

  1. Abbreviations: OR odds ratio, CI confidence interval, a χ2 test for genotype and allele distributions between the asthma group and the control group; b binary logistic regression for genotype distributions between the asthma group and the control group, adjusted for biological sex, age, BMI, ETS exposure and residence