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Table 7 Association between GAB1 gene SNVs and ICS response

From: Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children

SNVs

Genotypes

ICS responders

ICS nonresponders

p

pa

pb

rs1396527

      
 

G/G

22(52.4)

8(27.6)

0.036

0.038

0.642

 

G/T

16(38.1)

20(69.0)

 

T/T

4(9.5)

1(3.4)

rs17017425

      
 

T/T

25(59.5)

16(55.2)

0.760

0.715

> 0.999

 

T/C

13(31.0)

11(37.9)

 

C/C

4(9.5)

2(6.9)

rs1866756

      
 

G/G

23(54.8)

14(48.3)

0.283

0.591

0.265

 

G/A

16(38.1)

15(51.7)

 

A/A

3(7.1)

0(0.0)

rs3805236

      
 

A/A

22(52.4)

14(48.3)

0.542

0.734

0.510

 

A/G

18(42.9)

15(51.7)

 

G/G

2(4.8)

0(0.0)

rs3805246

      
 

G/G

23(54.8)

14(48.3)

0.230

0.591

0.265

 

G/A

16(38.1)

15(51.7)

 

A/A

3(7.1)

0(0.0)

rs3805254

      
 

A/A

23(54.8)

14(48.3)

0.230

0.591

0.265

 

A/G

16(38.1)

15(51.7)

 

G/G

3(7.1)

0(0.0)

  1. The values p < 0.05 were in bold
  2. a dominant model; b recessive model
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