Fig. 8From: Alveolar macrophage-derived gVPLA2 promotes ventilator-induced lung injury via the cPLA2/PGE2 pathwayHigh tidal volume mechanical ventilation promotes gVPLA2 secretion by alveolar macrophages, which in turn activates the intrapulmonary cPLA2/PGE2/Ca2 + pathway, leading to disrupted intracellular mitochondrial dynamics and mitochondrial dysfunction in lung tissueBack to article page