Fig. 2From: Whole-exome sequencing explored mechanism of selpercatinib resistance in RET-rearranged lung adenocarcinoma transformation into small-cell lung cancer: a case reportImaging in diagnosis and treatment. An enhanced CT image of this patient at follow-up. (A) At initial diagnosis. Arrows indicated mediastinal lymph nodes, left lung masses, and soft tissue metastases of the right ilium, but no lesions in the liver. (B) After 4 months, the mediastinal lymph nodes, right lung, and right iliac crest lesions became significantly smaller and was assessed as PR. (C) After 26 months, the right iliac lesion was enlarged, but the rest of the lesions were not. Assessed as oligoprogression. (D) 33 months after taking selpercatinib, the mediastinal lymph nodes were enlarged and multiple intrahepatic metastases appearedBack to article page