Fig. 6

Mutational Signatures at initial diagnosis and after transformation. Each individual mutation signature represents a different proportion of six types of base substitutions (C > A, C > G, C > T, T > A, T > C, T > G). Mutation signatures are characterized predominantly by C > T (signatures 1 A/B, 6, 7, 11, 15,19), C > A (4, 8, 18), T > C (5, 12, 16, 21) and T > G mutations (9, 17), and others showing distinctive combinations of mutation classes (2, 13, 14). The X-axis represented the samples at initial diagnosis and after transformation, and the Y-axis represented mutation frequency. Different mutational signatures were represented by different colors, as indicated in the legend