Table 2 Correlations between baseline HE4 level and some important clinical and routine laboratory parameters. Spearman’s test was performed when HE4 showed a moderate but statistically significant correlation with inflammation specific biomarkers, such as CRP, IL-6, ferritin, and WBC count. Among hematology parameters, HE4 had a positive association with serum ACE2 activity and PLT count, but inversely correlated with renal function. Abbreviations: CRP: C-reactive protein, IL-6: interleukin-6, AST: aspartate transaminase, ALT: alanine aminotransferase, LDH: lactate dehydrogenase, GFRCKD-EPI: Glomerular filtration rate - Chronic Kidney Disease Epidemiology Collaboration, ACE2: Angiotensin-converting enzyme 2, WBC: white blood cell, PLT: platelet
Demographical variables | Baseline HE4 (pmol/L) |
|---|---|
Age (years) | r = 0.349, p = 0.0015 |
SOFA-score | r = 0.659, p < 0.0001 |
Lung manifestation based on CT (%) | r = 0.353, p = 0.0096 |
Laboratory parameters | |
CRP (mg/L) | r = 0.407, p = 0.0002 |
IL-6 (ng/L) | r = 0.534, p < 0.0001 |
Ferritin (µg/L) | r = 0.502, p < 0.0001 |
Total LDH activity (U/L) | r = 0.431, p < 0.0001 |
GFR CKD-EPI (mL/min/1.73 m2) | r = -0.479, p < 0.0001 |
ACE2 activity (mU/L) | r = 0.434, p < 0.0001 |
WBC count (G/L) | r = 0.312, p = 0.0049 |
PLT count (G/L) | r = 0.231, p = 0.0395 |