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Table 3 Binary logistic regression analysis for testing baseline HE4 levels to predict individually the outcome and severity of COVID-19. Key demographical and some laboratory parameters were considered as confounders for this calculation. We have categorized all continuous variables, except for gender, into binary forms based on their medians (in case of HE4: 286.3 and 331.7 pmol/L, respectively). Abbreviations: CRP: C-reactive protein, IL-6: interleukin-6, ACE2: Angiotensin-converting enzyme 2, WBC count: white blood cell count, Lym count: lymphocyte count, PLT count: platelet count

From: Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia

Death/survival

Adjusted OR

95% CI

P-value

Age_bin

1.612

0.401

6.476

0.501

Gender

0.631

0.154

2.584

0.523

HE4_bin

10.618

2.331

48.354

0.002

CRP_bin

0.466

0.083

2.607

0.385

ACE2_bin

0.515

0.108

2.443

0.404

Ferritin_bin

5.911

1.194

29.259

0.029

Lym count_bin

0.175

0.033

0.925

0.040

PLT count_bin

1.155

0.257

5.181

0.850

IL-6_bin

5.605

1.516

20.724

0.010

WBC count_bin

5.435

1.152

25.626

0.032

Critical/severe

Adjusted OR

95% CI

P-value

Age_bin

1.117

0.322

3.868

0.861

Gender

0.995

0.290

3.413

0.994

HE4_bin

3.642

0.985

13.457

0.053

CRP_bin

0.846

0.200

3.568

0.820

ACE2_bin

1.027

0.285

3.702

0.967

Ferritin_bin

4.813

1.237

18.723

0.023

Lym count_bin

0.224

0.055

0.909

0.036

PLT count_bin

0.971

0.253

3.728

0.967

IL-6_bin

3.131

0.979

10.010

0.054

WBC count_bin

3.281

0.859

12.530

0.082