Exposure to air pollution concentrations of various intensities in early life and allergic sensitisation later in childhood

Ziou, Myriam; Gao, Caroline X.; Wheeler, Amanda J.; Zosky, Graeme R.; Stephens, Nicola; Knibbs, Luke D.; Williamson, Grant J.; Dalton, Marita F.; Dharmage, Shyamali C.; Johnston, Fay H.

doi:10.1186/s12890-023-02815-8

Table 3 Association between exposure to the various sources of PM_2.5, and sensitisation to various allergen categories and total IgE levels

From: Exposure to air pollution concentrations of various intensities in early life and allergic sensitisation later in childhood

Allergen categories	Prenatal		Postnatal
	Crude	Adjusted	Crude	Adjusted
	OR [95% CI]	OR_adj[95% CI]	OR [95% CI]	OR_adj[95% CI]
(A) Average fire-related PM_2.5
Dust	0.91 [0.79,1.05]	0.93 [0.81,1.08]	1.02 [0.88,1.18]	0.95 [0.80,1.12]
Cat	1.00 [0.88,1.14]	1.03 [0.90,1.18]	1.12 [0.95,1.33]	1.12 [0.93,1.35]
Grass	0.87 [0.72,1.04]	0.91 [0.76,1.09]	1.13 [0.97,1.31]	1.06 [0.90,1.24]
Fungi	0.95 [0.78,1.17]	1.01 [0.84,1.22]	1.14 [0.95,1.36]	1.09 [0.89,1.32]
Any	0.88 [0.77,1.01]	0.90 [0.78,1.03]	1.04 [0.90,1.20]	0.96 [0.82,1.13]
	β [95% CI]	β_adj[95% CI]	β [95% CI]	β_adj[95% CI]
Total IgE	−4.6 [−25.8,16.7]	−3.9 [−25.9,18.2]	−17.5 [− 49.2,14.2]	−27.4 [− 62.3,7.5]
(B) Peak fire-related PM_2.5
Dust	0.93 [0.79,1.09]	0.96 [0.82,1.13]	1.11 [0.72,1.69]	0.87 [0.52,1.45]
Cat	1.05 [0.89,1.24]	1.11 [0.93,1.32]	1.47 [0.89,2.44]	1.59 [0.89,2.83]
Grass	0.83 [0.65,1.05]	0.89 [0.71,1.13]	1.48 [0.95,2.30]	1.19 [0.72,1.96]
Fungi	1.02 [0.84,1.24]	1.11 [0.90,1.36]	1.32 [0.75,2.33]	1.15 [0.58,2.26]
Any	0.89 [0.76,1.04]	0.91 [0.78,1.07]	1.17 [0.76,1.79]	0.90 [0.55,1.48]
	β [95% CI]	β_adj[95% CI]	β [95% CI]	β_adj[95% CI]
Total IgE	−8.1 [−39.1,22.8]	−9.8 [− 42.7,23.1]	− 51.7 [− 144.8,41.3]	− 94.9 [− 204.2,14.3]
Allergen categories	Background
	Crude	Adjusted
	OR [95% CI]	OR_adj[95% CI]
(C) Background PM_2.5
Dust	1.96 [1.16,3.29]	1.90 [1.12,3.21]
Cat	1.39 [0.74,2.62]	1.38 [0.70,2.73]
Grass	1.67 [1.02,2.74]	1.52 [0.92,2.51]
Fungi	1.58 [0.77,3.28]	1.42 [0.70,2.84]
Any	1.44 [0.94,2.21]	1.42 [0.92,2.18]
	β [95% CI]	β_adj[95% CI]
Total IgE	39.0 [− 60.7138.6]	42.1 [−57.3141.4]

Note: Odds ratios and 95%CI from the crude models were estimated with univariable logistic regression/linear regression models incorporating only the outcome (logistic: sensitisation to allergen category, linear: total IgE levels) and a single pollutant. Odds ratios and 95%CI from the adjusted models incorporated all three exposures and maternal education, age in months, and IRSD. All estimates were scaled by IQR increase of the relevant pollutant. IgE Immunoglobulin E

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ISSN: 1471-2466

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