ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases

Table 4 Comparison of the clinical parameters between the patients with high and low monocyte ratio

Variable	IPF with high monocyte ratio	IPF with low monocyte ratio	Non-IPF with high monocyte ratio	Non-IPF with low monocyte ratio	P values
Total number, n (%)	26 (14)	30 (17)	62 (35)	61 (34)
Age, y	74 ± 6	72 ± 8	72 ± 10	71 ± 10	0.365
Male sex, n (%)	24 (92)	25 (83)	38 (61)	35 (57)	0.002
Blood biomarkers
LDH, IU/L	221.5 ± 63.1	203.1 ± 46.8	234.6 ± 97.4	208.8 ± 57.4	0.248
SP-D, ng/mL	147.9 ± 127.3	186.6 ± 150.8	180.0 ± 231.9	240.0 ± 310.1	0.503
KL-6, U/mL	689.5 ± 523.9	761.0 ± 344.6	918.5 ± 1185.4	877.2 ± 1384.8	0.130
Monocyte ratio, %	10.2 ± 1.2	6.6 ± 1.3	10.8 ± 2.8	6.7 ± 1.5	< 0.001
Monocyte count, /μL	721.6 ± 283.4	545.1 ± 186.4	646.8 ± 206.5	451.0 ± 165.1	< 0.001
HRCT scores
Honeycomb score, points	0.9 ± 1.7	2.5 ± 3.2	0.2 ± 0.6	0.3 ± 1.0	< 0.001
GGO score, points	4.3 ± 2.6	5.9 ± 2.2	4.8 ± 2.5	4.2 ± 3.5	0.001
ILD-GAP score	4.2 ± 0.8	3.8 ± 0.9	0.5 ± 1.0	0.6 ± 1.2	< 0.001
ILD-GAPM score	5.2 ± 0.8	3.8 ± 0.9	1.5 ± 1.0	0.6 ± 1.2	< 0.001
Pulmonary function tests
%FVC, %predicted	93.8 ± 20.7	93.2 ± 17.1	97.5 ± 18.0	91.6 ± 19.6	0.277
%D_Lco, %predicted	80.3 ± 32.4	82.0 ± 23.8	98.8 ± 33.3	97.7 ± 27.0	0.007

Serum SP-D could be measured in 122 patients (68%)
Abbreviations: GAP gender/age/physiology, GAPM gender/age/physiology/blood monocyte ratio, GGO ground-glass opacity, HRCT high-resolution computed tomography, ILD interstitial lung disease, IPF idiopathic pulmonary fibrosis, KL-6 Krebs von den Lungen-6, LDH lactate dehydrogenase, %D_Lco percentage predicted diffusion capacity of lung for carbon monoxide, %FVC percentage predicted forced vital capacity, SP-D surfactant protein-D

ISSN: 1471-2466