Fig. 2

Administration of OM-MSCs downregulates the expression of fibrotic factors from BLM-induced pulmonary fibrosis. (A-B) Representative images and quantification of COL1A1 staining of lung tissues from control mice or BLM-induced mice with or without OM-MSCs treatment. Scale bar: 200 mm. n = 4 per group. (C-D) Representative images and quantification of ACTA2 staining of lung tissues from control mice or BLM-induced mice with or without OM-MSCs treatment. Scale bar: 200 mm. n = 4 per group. (E-F) Representative images and quantification of MMP13 staining of lung tissues from control mice or BLM-induced mice with or without OM-MSCs treatment. Scale bar: 200 mm. n = 4 per group. (G) Measurement of hydroxyproline depositions in lung tissue of control mice or BLM-induced mice with or without OM-MSC treatment. n = 4 per group. (H-K) Representative western blot analysis and quantification of COL1A1, MMP13, ACTA2. n = 3 per group. Full-length blots/gels are presented in Supplementary file 2. (L-N) QPCR analysis of Col1a1, Mmp13, Acta2. n = 6 per group