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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: Olfactory mucosa mesenchymal stem cells alleviate pulmonary fibrosis via the immunomodulation and reduction of inflammation

Fig. 5

OM-MSCs ameliorate pulmonary fibrosis by modulating monocyte-derived macrophage phenotype. Pro-fibrotic macrophage can secrete TGF-β, TNF, IL1B and other factors to increase the number of myofibroblasts through EMT, thus producing more ECM and leading to fibrosis. OM-MSCs can reverse this process by altering the monocyte-derived macrophage phenotype

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BMC Pulmonary Medicine

ISSN: 1471-2466

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