Early bone loss in patients with obstructive sleep apnea: a cross-sectional study

Qiao, Yixian; Guo, Junwei; Luo, Jinmei; Huang, Rong; Wang, Xiaona; Su, Linfan; Xia, Weibo; Xiao, Yi

doi:10.1186/s12890-024-02848-7

BMC Pulmonary Medicine

Table 5 Stepwise multiple regression analysis of HR-pQCT parameters

From: Early bone loss in patients with obstructive sleep apnea: a cross-sectional study

Items		β-value	p-value	R²-value	F-value	P-value	Items		β-value	p-value	R²-value	F-value	P-value
Tt.Ar	NC	0.264	0.012	0.069	6.569	0.012	Tt.Ar	NC	0.295	0.005	0.087	8.383	0.005
Ct.Ar	BMI	0.363	0	0.259	9.995	0	Ct.Pm	NC	0.296	0.005	0.088	8.45	0.005
	Sleep efficiency	0.261	0.007				Ct.Ar	BMI	0.728	0	0.381	14.691	0
	P	-0.228	0.017					NC	-0.388	0.001
Th.Ar	NC	0.25	0.017	0.097	4.674	0.012		TG	0.218	0.014
Th.Ar	Age	0.218	0.036					Age	-0.176	0.045
Tt.vBMD	Age	-0.255	0.009	0.239	6.688	0	Tb.Ar	NC	0.289	0.005	0.12	5.945	0.004
	HDL-C	-0.187	0.056					Age	0.229	0.026
	Sleep efficiency	0.249	0.012				Tt.vBMD	Age	-0.364	0	0.386	13.341	0
	β-CTX	-0.245	0.014					BMI	0.619	0
Tb.vBMD	BMI	0.178	0.066	0.295	7.039	0		NC	-0.446	0
	Age	-0.247	0.009					WC/HC	-0.219	0.015
	Diabetes	0.22	0.022				Tb.vBMD	Age	-0.252	0.01	0.198	8.306	0
	Sleep efficiency	0.258	0.008					WC/HC	-0.312	0.002
	β-CTX	-0.24	0.013					BMI	0.3	0.003
Ct.vBMD	Age	-0.243	0.021	0.059	5.539	0.021	Ct.vBMD	β-CTX	-0.292	0.005	0.085	8.197	0.005
BV/TV	BMI	0.189	0.048	0.315	7.742	0	BV/TV	Age	-0.236	0.016	0.215	7.83	0
	Age	-0.263	0.005					WC/HC	-0.315	0.002
	Diabetes	0.23	0.015					BMI	0.304	0.002
	Sleep efficiency	0.252	0.008				Tb.N	WC/HC	-0.228	0.031	0.052	4.805	0.031
	β-CTX	-0.244	0.011				Tb.Th	BMI	0.508	0	0.232	8.678	0
Tb.N	HC	0.229	0.019	0.248	6.992			Age	-0.306	0.002
	Ca	-0.341	0.001		0			NC	-0.344	0.008
	Diabetes	0.299	0.003				Tb.Sp	β-CTX	0.219	0.034	0.095	4.575	0.013
	Age	-0.196	0.047					WC/HC	0.215	0.038
Tb.Th	BMI	0.272	0.005	0.256	7.324	0	Tb.1/N.SD	β-CTX	0.306	0.003	0.094	9.082	0.003
	Age	-0.237	0.014				Ct.Th	BMI	0.67	0	0.41	14.787	0
	Sleep efficiency	0.232	0.017					NC	-0.51	0
	Drink	0.217	0.025					Age	-0.284	0.001
Tb.Sp	HC	-0.208	0.031	0.275	6.375	0		BG	0.24	0.007
	Diabetes	-0.28	0.004				Ct.Po.Dm	WC	0.22	0.037	0.048	4.476	0.037
	Ca	0.324	0.001
	Age	0.233	0.018
	HDL-C	0.192	0.044
Tb.1/N.SD	TNF-α	0.209	0.026	0.31	6.225	0
	Ca	0.365	0
	Diabetes	-0.257	0.007
	Age	0.214	0.025
	HDL-C	0.233	0.014
	WC/HC	0.214	0.023
Ct.Th	BMI	0.441	0.001	0.186	6.078	0
	Sleep efficiency	0.235	0.017
	NC	-0.298	0.023
	Age	-0.197	0.044
Ct.Po	Sleep efficiency	0.243	0.016	0.194	5.119	0.001
	ALP	-0.21	0.039
	HDL-C	-0.239	0.02
	25-OHD	0.206	0.048

HR-pQCT high-resolution peripheral quantitative computed tomography, Tt.Ar total area, Ct.Pm cortical perimeter, Ct.Ar cortical area, Tb.Ar trabecular area, BMD bone mineral density, Tt.vBMD total volumetric vBMD, Tb.vBMD trabecular vBMD, Ct.vBMD cortical vBMD, BV/TV trabecular bone volume fraction, Tb.N trabecular number, Tb.Th trabecular thickness, Tb.Sp trabecular separation, Tb.1/N.SD trabecular bone heterogeneity, Ct.Th cortical thickness, Ct.Po intra-cortical porosity, Ct.Po.Dm cortical pore diameter, NC neck circumference, WC waist circumference, HC hip circumference, BMI body mineral index, HDL-C serum high-density lipoprotein cholesterol, P Phosphorus, β-CTX β-C-terminal telopeptide of type I collagen, Ca calcium, TG triglycerides, TNF-α Tumor necrosis factor, ALP alkaline phosphatase, BG blood glucose, 25-OHD total 25- hydroxyvitamin D

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ISSN: 1471-2466

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