| Survivor (n = 25) | Nonsurvivor (n = 40) | P value |
---|---|---|---|
Demographics | |||
    Age, years, median | 75 | 72.5 | 0.212 |
    Male | 13(52) | 30(75) | 0.057 |
    Body mass index, kg/m2, median | 21.04 | 23.17 | 0.229 |
    BMI* < 18 | 7(28) | 5(14.7) | 0.210 |
    BMI* > 24 | 9(36) | 14(41.2) | 0.687 |
    Vaccination doses, median | 2 | 2 | 0.890 |
     Ever vaccinated | 17(68) | 28(70) | 0.865 |
     Full vaccination (> = 3 doses) | 12(48) | 12(48) | 0.875 |
    DNR* | 15(60) | 32(80) | 0.080 |
    Smoker | 3(12) | 17(42.5) | 0.024 |
    Cerebrovascular disease | 4(16) | 2(5) | 0.194 |
    Dementia | 2(8) | 3(7.5) | 0.941 |
    Heart failure | 1(4) | 0(0) | 0.202 |
    Peripheral vascular disease | 1(4) | 1(2.5) | 0.733 |
    Diabetes mellitus | 9(36) | 13(32.5) | 0.772 |
    Chronic kidney disease | 3(12) | 9(22.5) | 0.288 |
    End stage renal disease | 1(4) | 4(10) | 0.377 |
    Chronic obstructive pulmonary disease | 2(8) | 2(5) | 0.624 |
    Chronic oxygen use | 2(8) | 1(2.5) | 0.304 |
    Admitted due to COVID-19 | 12(48) | 20(50) | 0.875 |
    Infected during hospitalization | 3(12) | 9(22.5) | 0.344 |
    Hematological malignancy | 1(4) | 6(15) | 0.235 |
Laboratory data on the day of respiratory failure (median) | |||
    White blood cells, 109/L | 8500 | 12,450 | 0.006 |
    Absolute neutrophil count, 109/L | 6318.7 | 7105.45 | 0.345 |
    Hemoglobin, g/dL | 11.5 | 10.5 | 0.153 |
    Absolute lymphocyte count, 109/L | 639.58 | 531.40 | 0.571 |
    Albumin, g/dL | 3.1 | 3.1 | 0.349 |
    C-reactive protein, mg/dL | 4.78 | 7.16 | 0.157 |
    Procalcitonin, ng/mL | 0.51 | 1.42 | 0.375 |
    Ferritin, ng/mL | 673.5 | 3220 | < 0.001 |
    Lactic dehydrogenase, U/L | 256 | 534.5 | < 0.001 |
    Lactate, mg/dL | 15.7 | 33 | 0.005 |
    D-dimer, ug/mL | 1.570 | 4.605 | 0.007 |
    Fibrinogen, mg/dL | 435.6 | 358 | 0.188 |
    Platelet count, /uL | 159,000 | 154,000 | 0.422 |
Severity on the day of respiratory failure | |||
    PaO2/FiO2 ratio, median | 148 | 125.39 | 0.364 |
    SOFA* score, median | 7 | 10 | 0.071 |
    APACHE* II score, median | 22 | 25.5 | 0.160 |
    MAP score**, median | 1 | 3 | 0.048 |
    GCS*, median | 9 | 7.5 | 0.995 |
    Vasopressor use | 6(24) | 22(55) | 0.014 |
Treatment | |||
    Cancer treatment in 4 weeks prior to COVID-19 diagnosis | 12(48) | 22(55) | 0.583 |
    Cytotoxic chemotherapy in 4 weeks prior to COVID-19 diagnosis | 8(32) | 11(27.5) | 0.698 |
    Mechanical ventilation | 18(72) | 24(60) | 0.325 |
    Re-application of MV* after weaning | 2(8) | 2(5) | 0.624 |
    Tracheostomy | 3(12) | 1(2.5) | 0.121 |
    New renal replacement therapy during admission | 1(4) | 9(22.5) | 0.044 |
    Extracorporeal membrane oxygenation | 0(0) | 5(12.5) | 0.066 |
    Tocilizumab | 9(36) | 21(52.5) | 0.194 |
    Remdesivir | 22(88) | 37(92.5) | 0.542 |
    Nirmatrelvir/ritonavir | 1(4) | 3(7.5) | 0.568 |
    Molnupiravir | 1(4) | 1(2.5) | 0.733 |
    Enoxaparin | 9(36) | 13(32.5) | 0.772 |
    Corticosteroid | 22(88) | 39(97.5) | 0.121 |
Complications | |||
    CMV* infection | 2(8) | 14(35) | 0.048 |
    Gastrointestinal bleeding | 6(24) | 11(27.5) | 0.755 |
    Thromboembolism | 3(12) | 4(10) | 0.800 |
Outcome | |||
    ICU* admission | 20(80) | 28(70) | 0.372 |
    Hospital length of stay, days, median | 33 | 21.5 | 0.082 |
    Ventilator days, median | 10 | 5.5 | 0.710 |
    Time from symptoms onset to 1st Ct* > 30, days | 14 | 11.5 | 0.721 |
    Prolonged shredding (> 10 days) | 18(72) | 21(52.5) | 0.118 |