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Table 2 Multivariate cox analysis of acetylcholine and prognosis in patients with PH

From: Circulating acetylcholine serves as a potential biomarker role in pulmonary hypertension

Variables

HR

95% CI

P value

Unadjusted

3.733

2.264–6.156

< 0.001

Adjusteda

2.450

1.414–4.247

0.001

Adjustedb

1.958

1.141–3.362

0.015

  1. PH: pulmonary hypertension; CI: confidence interval; 6 MWD: 6-minute walk distance; WHO-FC: world health organization function class; RVD: right ventricular diameter; TAPSE: tricuspid annular plane systolic excursion
  2. aAdjusted for age, prostacyclins, PH subtypes, albumin, and comorbidities including coronary heart disease and chronic kidney disease
  3. bAdjusted for 6 MWD, WHO-FC, and echocardiographic parameters including RVD and TAPSE