Table 2 Top pathways from KEGG, WikiPathways, Reactome and BioCarta databases and their corresponding P-values and genes for common differentially expressed genes

KEGG

Mismatch repair

0.015985227

PCNA

Base excision repair

0.022861069

PCNA

DNA replication

0.024915106

PCNA

Cell cycle

0.003304756

RB1;PCNA

Bladder cancer

0.028329595

RB1

Ferroptosis

0.028329595

FTH1

Nucleotide excision repair

0.032412327

PCNA

Hepatitis B

0.005566263

RB1;PCNA

Fanconi anemia pathway

0.03715538

UBE2T

Kaposi sarcoma-associated herpesvirus infection

0.007811021

RB1;HIF1A

WikiPathways

LncRNA-mediated mechanisms of therapeutic resistance WP3672

0.00419312

HIF1A

Pilocytic astrocytoma WP2253

0.00419312

NF1

MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma WP3593

0.004890388

HIF1A

HIF1A and PPARG regulation of glycolysis WP2456

0.005587202

HIF1A

Glycolysis in senescence WP5049

0.007674931

RB1

NAD metabolism, sirtuins and aging WP3630

0.007674931

HIF1A

Iron metabolism in placenta WP2007

0.008369936

FTH1

Aryl Hydrocarbon Receptor Netpath WP2586

0.000462719

RB1;NF1

H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity WP3969

0.009758591

RB1

ID signaling pathway WP53

0.01114544

RB1

Reactome

PTK6 Expression R-HSA-8849473

0.003495399

HIF1A

SARS-CoV-1 Genome Replication And Transcription R-HSA-9679514

0.003495399

RB1

SARS-CoV-2 Genome Replication And Transcription R-HSA-9694682

0.003495399

RB1

NOSTRIN Mediated eNOS Trafficking R-HSA-203641

0.003495399

CAV1

PTK6 Promotes HIF1A Stabilization R-HSA-8857538

0.00419312

HIF1A

RAS Signaling Downstream Of NF1 Loss-Of-Function Variants R-HSA-6802953

0.00419312

NF1

CD163 Mediating An Anti-Inflammatory Response R-HSA-9662834

0.006283564

PLK2

Condensation Of Prometaphase Chromosomes R-HSA-2514853

0.006979474

NCAPD2

STAT3 Nuclear Events Downstream Of ALK Signaling R-HSA-9701898

0.006979474

HIF1A

eNOS Activation R-HSA-203615

0.007674931

CAV1

BioCarta

p53 Signaling Pathway Homo sapiens h p53Pathway

3.53E-05

RB1;PCNA

Overview of telomerase RNA component gene hTerc Transcriptional Regulation Homo sapiens h tercPathway

0.004890388

RB1

VEGF, Hypoxia, and Angiogenesis Homo sapiens h vegfPathway

0.000195723

CAV1;HIF1A

BTG family proteins and cell cycle regulation Homo sapiens h btg2Pathway

0.006283564

RB1

Cyclin E Destruction Pathway Homo sapiens h fbw7Pathway

0.006283564

RB1

E2F1 Destruction Pathway Homo sapiens h skp2e2fPathway

0.006979474

RB1

Regulation of transcriptional activity by PML Homo sapiens h pmlPathway

0.007674931

RB1

Regulation of p27 Phosphorylation during Cell Cycle Progression Homo sapiens h p27Pathway

0.009064489

RB1

RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage Homo sapiens h rbPathway

0.009064489

RB1

Erythropoietin mediated neuroprotection through NF-kB Homo sapiens h eponfkbPathway

0.009064489

HIF1A