Fig. 1

Schedule of intervention delivery. All participants received their first intervention visit at least 4 weeks following consent (so that the consultation is based on at least 4 weeks of adherence data). This visit was always done face-to-face including, hospital (in-patient), clinic, or home. All participants received an intermediate review phone call one week later. Subsequent visits depended on their adherence level. Participants with adherence of ≥ 80% followed the 'Very high adherence' pathway; those with adherence < 80% followed the normal pathway. Participants on the ‘Very high adherence’ pathway had intervention sessions over a 4-week period. In addition to the first intervention session (week 0) and an intermediate review (week 1) they received a phase review at week 4. They then received a phase review session every 12 weeks. Participants on the normal pathway had intervention sessions over a 12-week period. In addition to the first intervention session (week 0) and an intermediate review (week 1) they received a review session at week 4, an intermediate review at week 6, a second review session at weeks 8 or 9 and a phase review at week 12. This pattern of delivery constitutes a phase