Table 1 Comparison between pneumococcal vaccinated and unvaccinated elderly pneumonia patients
Total (N = 4515) | Pneumococcal vaccinated (N = 1609) | Unvaccinated (N = 2906) | P-value | |
|---|---|---|---|---|
Age (years), mean (1st quartile;3rd quartile) | 77.0 [71.0;82.0] | 76.0 [71.0;82.0] | 78.0 [72.0;83.0] | < 0.001*** |
Sex | ||||
Male, n (%) | 2446 (54.2) | 907 (56.4) | 1539 (53.0) | 0.030* |
Smoking status (n = 4340), n (%) | ||||
Current | 333 (7.7) | 104 (6.8) | 229 (8.2) | < 0.001*** |
Ex-smoker less than 1Y | 65 (1.5) | 28 (1.8) | 37 (1.3) | |
Ex-smoker more than 1Y | 688 (15.9) | 287 (18.7) | 401 (14.3) | |
Never | 3254 (75.0) | 1112 (72.6) | 2142 (76.3) | |
CURB-65 | ||||
Confusion (n = 4458), n (%) | 238 (5.3) | 61 (3.9) | 177 (6.2) | 0.001*** |
Urea (mg/dl) (n = 4515), mean [1st quartile;3rd quartile] | 17.0 [13.0;22.5] | 16.5 [13.0;21.8] | 17.0 [13.0;23.0] | 0.018* |
Urea (>20 mg/dl), n (%) | 1458 (32.3) | 480 (29.8) | 978 (33.7) | 0.009** |
SBP (mmHg) (n = 4458), mean [1st quartile;3rd quartile] | 124.0 [110.0;140.0] | 125.0 [110.0;140.0] | 123.0 [110.0;140.0] | 0.627 |
DBP (mmHg) (n = 4458), mean [1st quartile;3rd quartile] | 71.5 [66.0;80.0] | 72.0 [67.0;80.0] | 71.0 [66.0;80.0] | 0.957 |
SBP<90mmHg or /DBP≤60mmHg, n (%) | 347 (7.7) | 109 (6.8) | 238 (8.2) | 0.099 |
RR (rate/min), mean [1st quartile;3rd quartile] | 20.0 [20.0;20.0] | 20.0 [20.0;20.0] | 20.0 [20.0;20.0] | 0.002** |
RR ≥30 rate/min, n (%) | 77 (1.7) | 20 (1.2) | 57 (2.0) | 0.096 |
CCI scores, mean [1st quartile;3rd quartile] | 3.0 [2.0;5.0] | 3.0 [2.0;5.0] | 3.0 [2.0;5.0] | 0.742 |
GW, n (%) | 4218 (93.4) | 1534 (95.3) | 2684 (92.4) | < 0.001*** |
ICU, n (%) | 297 (6.6) | 75 (4.7) | 222 (7.6) | |
Hospital days, mean [1st quartile;3rd quartile] | 9.0 [7.0;13.0] | 9.0 [7.0;12.0] | 9.0 [7.0;13.0] | 0.038* |
In-hospital improved, n (%) | 4331 (95.9) | 1571 (97.6) | 2760 (95.0) | < 0.001*** |
30-day mortality, n (%) | 197 (4.4) | 42 (2.6) | 155 (5.3) | < 0.001*** |
Comorbidities, n (%) | ||||
MI | 151 (3.6) | 51 (3.4) | 100 (3.8) | 0.586 |
CHF | 778 (18.6) | 261 (17.3) | 517 (19.4) | 0.096 |
PVD | 1100 (26.3) | 393 (26.0) | 707 (26.5) | 0.732 |
Rheumatoid | 236 (5.6) | 85 (5.6) | 151 (5.7) | 1.000 |
Cerebrovascular disease | 1061 (25.4) | 374 (24.7) | 687 (25.8) | 0.479 |
Dementia | 869 (20.8) | 278 (18.4) | 591 (22.2) | 0.004** |
Hemiplegia or paraplegia | 74 (1.8) | 22 (1.5) | 52 (2.0) | 0.295 |
Chronic pulmonary disease | 3042 (72.8) | 1117 (73.9) | 1925 (72.2) | 0.267 |
Chronic kidney disease | 257 (6.2) | 91 (6.0) | 166 (6.2) | 0.838 |
Mild liver disease | 1325 (31.7) | 486 (32.1) | 839 (31.5) | 0.684 |
Serious Liver disease | 21 (0.5) | 7 (0.5) | 14 (0.5) | 0.963 |
DM (with or without complication) | 1785 (39.5) | 653 (40.6) | 1132 (39.0) | 0.298 |
Any malignancy | 380 (9.1) | 140 (9.3) | 240 (9.0) | 0.827 |
Metastatic solid tumor | 26 (0.6) | 12 (0.8) | 14 (0.5) | 0.393 |
AIDS | 0 (0.0) | 0 (0.0) | 0 (0.0) | - |
Antibiotics | ||||
Days, mean [1st quartile;3rd quartile] | 8.0 [6.0;12.0] | 8.0 [6.0;12.0] | 8.0 [6.0;12.0] | 0.102 |
Beta-lactam, n (%) | 2462 (54.5) | 889 (55.3) | 1573 (54.1) | 0.220 |
Quinolone, n (%) | 600 (13.3) | 204 (12.7) | 396 (13.6) | |
Beta-lactam + macrolide, n (%) | 413 (9.1) | 162 (10.1) | 251 (8.6) | |
Beta-lactam + quinolone, n (%) | 1040 (23.0) | 354 (22.0) | 686 (23.6) | |