Table 2 Associations between healthcare resource use and nintedanib adherence trajectory

Any all-cause inpatient hospital event

 Unadjusted mean

20.40%

22.80%

30.00%

29.40%

26.80%

 Unadjusted mean difference (95% CI)

ref

2.4% (− 4.0%, 8.9%)

9.6% (2.5%, 16.8%)

9.1% (2.8%, 15.3%)

6.4% (1.1%, 11.7%)

  P-value

0.46

0.008

0.005

0.02

 Adjusted mean difference (95% CI)

ref

2.4% (− 4.0%, 8.7%)

9.1% (2.2%, 16.0%)

8.0% (1.8%, 14.2%)

4.3% (− 0.8%, 9.4%)

  P-value

0.46

0.009

0.011

0.096

Count of all-cause inpatient hospital days

 Unadjusted mean

1.4

1.4

3.4

2

2.5

 Unadjusted mean difference (95% CI)

ref

0.0 (− 0.7, 0.7)

2.0 (0.7, 3.3)

0.7 (0.0, 1.3)

1.1 (0.4, 1.9)

  P-value

0.94

0.003

0.07

0.003

 Adjusted mean difference (95% CI)

ref

0.0 (− 0.7, 0.8)

1.8 (0.6, 2.9)

0.5 (− 0.1, 1.2)

0.8 (0.1, 1.5)

  P-value

0.9

0.003

0.11

0.02

Total all-cause medical spending

 Unadjusted mean

$12,648

$13,581

$17,550

$15,375

$18,110

 Unadjusted mean difference (95% CI)

ref

$933 (−$1,880, $3,746)

$4,902 ($768, $9,036)

$2,727 ($323, $5,131)

$5,462 ($2,521, $8,404)

  P-value

0.52

0.02

0.03

< 0.001

 Adjusted mean difference (95% CI)

ref

$523 (−$1,488, $2,534)

$4,876 ($1,470, $8,282)

$3,639 ($1,322, $5,955)

$3,907 ($1,658, $6,156)

  P-value

0.61

0.005

0.002

< 0.001

Any IPF-related inpatient hospital event

 Unadjusted mean

10.80%

11.40%

19.50%

14.10%

12.20%

 Unadjusted mean difference (95% CI)

ref

0.6% (− 4.3%, 5.5%)

8.7% (2.7%, 14.8%)

3.4% (− 1.4%, 8.2%)

1.4% (− 2.6%, 5.4%)

  P-value

0.8

0.005

0.17

0.49

 Adjusted mean difference (95% CI)

ref

0.8% (− 4.0%, 5.7%)

8.4% (2.5%, 14.2%)

3.0% (− 1.9%, 7.9%)

0.4% (− 3.4%, 4.2%)

  P-value

0.74

0.005

0.23

0.84

Count of IPF-related inpatient hospital days

 Unadjusted mean

0.7

0.6

1.9

0.7

0.9

 Unadjusted mean difference (95% CI)

ref

−0.2 (− 0.5, 0.2)

1.2 (0.3, 2.1)

0.0 (− 0.4, 0.4)

0.2 (− 0.2, 0.7)

  P-value

0.37

0.01

0.98

0.34

 Adjusted mean difference (95% CI)

ref

−0.2 (− 0.5, 0.1)

1.2 (0.4, 2.1)

0.1 (− 0.3, 0.5)

0.2 (− 0.2, 0.6)

  P-value

0.29

0.005

0.64

0.34

Total IPF-related medical spending

 Unadjusted mean

$3,240

$2,936

$6,012

$3,697

$3,861

 Unadjusted mean difference (95% CI)

ref

−$304 (−$1,075, $467)

$2,772 ($422, $5,122)

$457 (−$459, $1,372)

$621 (−$772, $2,014)

  P-value

0.44

0.02

0.33

0.38

 Adjusted mean difference (95% CI)

ref

−$299 (−$1,080, $482)

$2,205 ($455, $3,955)

$743 (−$244, $1,729)

$66 (−$815, $948)

  P-value

0.45

0.014

0.14

0.88

Sample size, n (%)

781 (43.4)

202 (11.2)

190 (10.6)

255 (14.2)

370 (20.6)