Fig. 5

Improvement of hyperoxia-induced lung tissue injury by IRF4 knockout. a HE staining of lung tissues from mice in the WT-hyperoxia and KO-hyperoxia groups (Scale bar = 10 μm; 400×), showed a significant increase in radial alveolar count, and a significant decrease in mean linear intercept. b Western blot analysis of SP-C and T1α protein expression levels in the lung tissues of WT-hyperoxia and KO-hyperoxia groups. c ELISA of IL-6 and IL-17 A expression in the mouse lung tissues of WT-hyperoxia and KO-hyperoxia groups. The representative data from five independent experiments. Data are presented as mean ± SD (n = 5, t-test one-way); *P < 0.05 and **P < 0.01 vs. WT-hyperoxia