Fig. 3
From: Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports
Evolution of mPAP and TAPSE over time. mPAP is shown with filled circles on the left-hand side, and the TAPSE with open triangles on the right-hand side. Each point indicates one observation, and the lines are added to help visualize the change over time. Normal TAPSE ≥ 18 mm [33]. Note that the time scale of the horizontal axis is not constant. Time points ≤ 0 indicate the period during scurvy. Vitamin C administration was started soon after the time point 0. Data are for: (A) a 40-year-old male in France [80], (B) a 7-year-old boy in Malaysia [103], (C) a 2-year-old girl in Japan [95], (D) a 3-year-old boy in Japan [89], (E) a 40-year-old female in Finland [90], (F) a 17-year-old male in the USA [85], (G) a 6-year-old boy in the USA [98], (H) a 66-year-old male in Italy [87]. See extraction of data in Supplementary files 1 and 2. TAPSE, tricuspid annular plane systolic excursion