Table 1 Antifibrotic group (Cohort 1, N = 167) and Control group (cohort 2, N = 180,586) characteristics before and after propensity score matching

Cohort

Patients

Mean ± SD

P-Value

Std diff.

Mean ± SD

Patients

P-Value

Std diff.

1

AI

Age at Index

167

64.5 +/- 11.6

0.126

0.137

64.5 +/- 11.6

167

100%

0.323

2

180,586

62.6 +/- 16.5

65.8 +/- 11.8

167

100%

Cohort

Patients

% of Cohort

P-Value

Std diff.

Patients

% of Cohort

P-Value

Std diff.

1

2106-3

White

126

75.4%

<0.001

0.288

126

75.4%

0.024

0.250

2

117,798

62.2%

107

64.1%

1

2054-5

Black or African

18

10.8%

0.132

0.124

18

10.8%

0.011

0.281

2

American

28,266

14.9%

35

21.0%

1

M

Male

99

59.3%

0.073

0.140

99

59.3%

1

<0.001

2

99,085

52.3%

99

59.3%

1

F

Female

64

38.3%

0.198

0.101

64

38.3%

1

<0.001

2

81,886

43.3%

64

38.3%

1

2028-9

Asian

10

6.0%

0.100

0.111

10

6.0%

1

<0.001

2

6,835

3.6%

10

6.0%

1

2131-1

Other Race

10

6.0%

0.129

0.104

10

6.0%

1

<0.001

2

7,106

3.8%

10

6.0%

Cohort

Patients

% of Cohort

P-Value

Std diff.

Patients

% of Cohort

P-Value

Std diff.

1

I20-I25

Ischemic heart

49

29.3%

0.003

0.215

49

29.3%

1

<0.001

2

diseases

38,072

20.1%

49

29.3%

1

E08-E13

Diabetes mellitus

46

27.5%

0.849

0.015

46

27.5%

1

<0.001

2

50,899

26.9%

46

27.5%

1

E40-E46

Malnutrition

11

6.6%

0.141

0.102

11

6.6%

0.822

0.025

2

8,104

4.3%

10

6.0%

1

C34

Malignant neoplasm of bronchus and lung

10

6.0%

<0.001

0.259

10

6.0%

1

<0.001

2

2,272

1.2%

10

6.0%

1

Z87.891

Personal history of nicotine dependence

39

23.4%

0.003

0.210

39

23.4%

0.282

0.118

2

28,627

15.1%

31

18.6%

1

Z72.0

Tobacco use

10

6.0%

0.059

0.125

10

6.0%

1

<0.001

2

6,347

3.4%

10

6.0%

1

K70

Alcoholic liver

10

6.0%

<0.001

0.286

10

6.0%

1

<0.001

2

disease

1,597

0.8%

10

6.0%

Cohort

Patients

% of Cohort

P-Value

Std diff.

Patients

% of Cohort

P-Value

Std diff.

1

HS050

ADRENAL

114

68.3%

<0.001

0.393

114

68.3%

1

<0.001

2

CORTICOSTEROIDS

93,286

49.3%

114

68.3%

1

3264

dexamethasone

61

36.5%

0.015

0.181

61

36.5%

0.219

0.135

2

53,188

28.1%

72

43.1%

1

6902

methylprednisolone

61

36.5%

<0.001

0.288

61

36.5%

0.246

0.127

2

44,376

23.4%

51

30.5%

1

5492

hydrocortisone

17

10.2%

0.680

0.031

17

10.2%

0.312

0.111

2

17,517

9.3%

23

13.8%

1

8640

prednisone

62

37.1%

<0.001

0.382

62

37.1%

0.164

0.153

2

38,179

20.2%

50

29.9%

1

2,284,718

remdesivir

10

6.0%

0.592

0.040

10

6.0%

1

<0.001

2

9,611

5.1%

10

6.0%

1

612,865

tocilizumab

10

6.0%

<0.001

0.322

10

6.0%

0.001

0.357

2

760

0.4%

0

0%

1

2,047,232

baricitinib

10

6.0%

<0.001

0.318

10

6.0%

1

<0.001

2

843

0.4%

10

6.0%