Lung transcriptomics reveals the underlying mechanism by which aerobic training enhances pulmonary function in chronic obstructive pulmonary disease

Table I Top 10 genes upregulated in MG vs. CG but downregulated in EG vs. MG, sorted by magnitude of Log-fold change

Gene ID	Symbol	Name	P-Value	Log FC
327,799	Usp44	Ubiquitin specific peptidase 44	0.0053	6.29
11,418	Asic2	Acid-sensing (proton-gated) ion channel 2	0.0051	6.09
23,925	Kel	Kell blood group	0.0071	6.08
14,761	Gpr27	G protein-coupled receptor 27	0.0037	6.08
100,038,683	Gm10775	Predicted gene 10,775	0.0051	6.04
74,176	Tgm5	Transglutaminase 5	0.0076	5.75
243,168	Hsd17b13	Hydroxysteroid (17-beta) dehydrogenase 13	0.0121	5.75
240,595	Kcnv2	Potassium channel, subfamily V, member 2	0.0277	5.72
629,147	Ctxn3	Cortexin 3	0.0178	5.68
436,240	Foxr2	Forkhead box R2	0.0105	5.67

Note: log FC, log (fold-change). The above DEGs were upregulated after smoke exposure but downregulated after exercise training, indicating that the effect of exercise training on lung tissue might be related to the above genes.

ISSN: 1471-2466