Lung transcriptomics reveals the underlying mechanism by which aerobic training enhances pulmonary function in chronic obstructive pulmonary disease

Table II Top 10 genes downregulated in CG vs. MG but upregulated in EG vs. MG, sorted by magnitude of Log-fold change

Gene ID	Symbol	Name	P-Value	Log FC
18,509	Pax7	Paired box 7	0.0058	7.27
192,167	Nlgn1	Neuroligin 1	0.0137	6.89
14,402	Gabrb3	Gamma-aminobutyric acid (GABA) A receptor	0.0161	5.78
13,615	Edn2	Endothelin 2	0.0231	5.27
171,382	Trpm8	Transient receptor potential cation channel, subfamily M, member 8	0.0461	4.16
223,645	Mroh6	Maestro heat-like repeat family member 6	0.0283	3.65
20,339	Sele	Selectin, endothelial cell	0.0014	2.74
193,740	Hspa1a	Heat shock protein 1 A	0.0011	2.41
15,109	Hal	Histidine ammonia lyase	0.0288	1.88
20,302	Ccl3	Chemokine (C-C motif) ligand 3	0.0037	1.79

Abbreviation: logFC, log (fold-change). The above DEGs were downregulated after smoke exposure but upregulated after exercise training, indicating that the effect of exercise training on lung tissue might be related to the above upregulated genes.

ISSN: 1471-2466