Bronchiectasis-associated infections and outcomes in a large, geographically diverse electronic health record cohort in the United States

Table 4 Exacerbations and hospitalizations following incident bronchiectasis diagnosis by respiratory co-infection status^a

	N	Exacerbation				Hospitalization
		One year (no. %)	Two year (no. %)	Rate per person-year^b	One year (no. %)	Two year (no. %)	Rate per person-year^b
Total	5795	1521 (26)	1861 (32)	0.24	3016 (52)	3462 (60)	0.61
Pseudomonas aeruginosa	139	69 (50)*	89 (64)*	0.86	113 (81)*	121 (87)*	1.42
Mycobacterium avium complex	56	15 (27)*	21 (38)*	0.20	30 (54)*	36 (64)*	0.56
Staphylococcus aureus	44	19 (43)	22 (50)	0.59	34 (77)	36 (82)	1.16
Aspergillus species	35	11 (31)	14 (40)	0.23	30 (86)	31 (89)	0.73
Stenotrophomonas. maltophilia	27	17 (63)	19 (70)	0.75	22 (81)	25 (93)	1.48
Mycobacterium abscessus	12	4 (33)	5 (42)	0.31	9 (75)	9 (75)	0.79
Haemophilus influenzae	8	4 (50)	5 (62)	0.38	4 (50)	5 (62)	0.93
Streptococcus pneumoniae	7	4 (57)	4 (57)	0.73	5 (71)	6 (86)	0.90
Klebsiella pneumoniae	6	3 (50)	3 (50)	0.86	4 (67)	5 (83)	1.39
Chronic infection with any of above organisms^c	301	130 (43)	161 (53)	0.59	224 (74)	246 (82)	1.12
No chronic infection with above organisms^c	5494	1391 (25)	1700 (31)	0.22	2792 (51)	3216 (59)	0.59

^aExacerbation ICD9/10 codes: 494.1, 493.02, 493.12, 493.22, 493.92; J44.1, J45.21, J45.31, J45.41, J45.51, J45.901, J47.0, J47.1
^bTime period of 30 days prior to incident bronchiectasis encounter through the end of the study period
^cRelative Risk of Exacerbations,. chronic infections vs no infections: One year: 1.7 (1.4, 2.0); 2 years; 1.7 (1.5, 2.0); Relative risk of hospitalizations: One year- 1.5 (1.3, 1.7)- Two years- 1.4 (1.2, 1.6)

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