Table 3 Cases with anti-synthetase syndrome and pneumomediastinum
From: Anti-synthetase syndrome in a child with pneumomediastinum: a case report and literature review
Reference | Age/sex | Primary disease | symptoms | Imaging | Drug Treatment | Intubation | Outcome | Diagnosis |
|---|---|---|---|---|---|---|---|---|
Saint-Georges [9] | 63Y/Female | Anti-synthetase syndrome | Fever; muscle ache; dyspnea; cough; facial papules-erythema predominantly on the eyelids | Extensive stripe shadow in both lungs; diffuse ground glass opacity; pneumomediastinum; pneumothorax | Corticosteroids; human immunoglobulin; immunosuppressants | Yes | Died | Anti-synthetase syndrome; pneumomediastinum; pneumonia; pulmonary fibrosis; acute respiratory failure; hypoxemia |
Vinicki [10] | 50Y/male | Hypothyroidism; type 2 diabetes; hypertension | Intermittent fever, weight loss, generalized muscle weakness, progressive dyspnea, facial erythema, scaly papules on the fingers | Pulmonary interstitial involvement with little ground glass, pneumomediastium, subcutaneous emphysema | Methylprednisone, azathioprine | No | Recovered | Anti-synthetase syndrome; pneumomediastinum; hypothyroidism; type 2 diabetes; hypertension |
Jhajj [8] | 48Y/male | Diabetic | Cough, low-grade fever, erythroderma over the ears and radial aspect of the fingers, weight loss, arthralgia | Patchy multifocal areas of peripheral airspace disease in the lungs with moderate fatty liver infiltration, pneumomediastium, subcutaneous emphysema | Prednisone, azathioprine, mycophenolate, hydroxychloroquine, rituximab, double lung transplant, tacrolimus | Yes | Recovered | Anti-synthetase syndrome; pneumomediastinum |