Table 1 Characteristics of adult subjects with COPD from the UK Biobank

Sex

25,981

29,801

24.72

< 0.001^c

 Female

13,163 (50.7)

11,464 (38.5)

 Male

12,818 (49.3)

18,337 (61.5)

Age at recruitment (years)

25,981

57.6 ± 7.8

29,801

60.5 ± 6.9

38.71

< 0.001^a2

Ethnicity

25,981

29,801

0

< 0.001^c

 British

24,446 (94.1)

28,057 (94.1)

 Irish

653 (2.5)

899 (3.0)

 Any other white background

882 (3.4)

845 (2.8)

Body mass index (BMI) (Kg/m²)

25,981

28.2 ± 4.4

29,743

25.3 ± 4.2

-67.3

< 0.001^a2

FEV1, percent predicted

25,981

79.7 ± 17.8

29,801

78.7 ± 19.1

-5.5

< 0.001^a2

FEV1, GOLD stage

25,981

29,801

8.43

< 0.001^c

 > 80% (mild)

13,298 (51.2)

14,842 (49.8)

 50–79% (moderate)

11,242 (43.3)

12,653 (42.5)

 30–49% (severe)

1,266 (4.9)

1,978 (6.6)

 < 30% (very severe)

175 (0.67)

328 (1.1)

FEV1, liters

25,981

2.4 ± 0.74

29,801

2.4 ± 0.79

-4

< 0.001^a2

FEV1/FVC ratio

25,981

0.65 ± 0.06

29,801

0.64 ± 0.07

-14.8

< 0.001^a2

Alcohol drinker status

25,961

29,758

5.45

< 0.001^c

 Never

699 (2.7)

981 (3.3)

< 0.001^d

 Previous

892 (3.4)

1,292 (4.3)

< 0.001^d

 Current

24,370 (93.9)

27,485 (92.4)

 < 0.001^d

Smoking status

25,871

29,656

7.66

< 0.001^c

 Never

10,686 (41.3)

11,981 (40.4)

0.0264^d

 Previous

10,732 (41.5)

11,460 (38.6)

< 0.001^d

 Current

4,453 (17.2)

6,215 (21.0)

 < 0.001^d

Pack years of smoking (years)

11,418

25.5 [14.0, 39.4]

13,407

27.5 [14.8, 42.0]

8.06

< 0.001^b

Ever addicted to any substance or behavior

7,782

622 (8.0)

8,203

612 (7.5)

-2

0.21^c

History of cancer diagnosis

25,891

2,001 (7.7)

29,698

2,754 (9.3)

5.54

< 0.001^c

Doctor diagnosed emphysema

6,010

56 (0.93)

6,425

101 (1.6)

5.76

0.001^c

Age emphysema diagnosed by doctor

56

54.4 ± 13.1

101

58.7 ± 11.1

35.23

0.032^a1

IPAQ activity group

21,263

23,966

8.39

< 0.001^c

 Low

3,698 (17.4)

4,539 (18.9)

 Moderate

8,379 (39.4)

9,745 (40.7)

 High

9,186 (43.2)

9,682 (40.4)

Summed minutes activity (minutes)

21,263

105.0 [60.0, 180.0]

23,966

100.0 [50.0, 180.0]

-6.5

< 0.001^b

MET minutes per week for walking (minutes/week)

21,263

693.0 [330.0, 1386.0]

23,966

693.0 [330.0, 1386.0]

-1.5

0.12^b